Brain-derived Neurotrophic Factor and Cogntive Function
NCT ID: NCT01390688
Last Updated: 2011-07-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
200 participants
OBSERVATIONAL
2009-06-30
2012-03-31
Brief Summary
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Brain-derived Neurotrophic factor (BDNF) is produced in brain as well as several tissues outside brain eg muscle cells. Low BDNF are associated with cognitive dysfuction, obesity and type 2 diabetes.
The investigators include 200 individuals divided into three groups: 80 individuals with type 2 diabetes, 80 age and BMI-matched controls and 40 individuals with impaired glucose tolerance.
The project will test the hypothesis, that low systemic BDNF are associated with accumulation of abdominal fat, cognitive dysfunction and insulin resistence with different effect in men and women.
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Detailed Description
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200 individuals in age 40-65 years are recruited and categorized into 3 groups: 1. Type 2 Diabetes, 2. Impaired glucose Tolerance and 3. Normal Glucose Tolerance. Groups are supposed to be age and BMI-matched.
Measurements of systemic BDNF, cogntive function (memory, attention and langue), fitness, bodycomposition, glucose metabolism and systemic inflammation are done.
Multiple regression analysis are perfomed to explain variablity in cognitive function, with age, visceral fat and BDNF as explanotory varibales.
Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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Type 2 Diabetes
80 individuals with type 2 Diabetes, confirmed by an OGTT, age 40-65 years, BMI \> 18.5 kg/m2 fatsing plasma glucose \< 12 mmol/l
No interventions assigned to this group
Impaired glucose tolerance
40 individuals with impaired glucose tolerance. age 40 -65 years, BMI \> 18. 5 kg/m2
No interventions assigned to this group
Normal glucose tolerance
80 Individuals without type 2 diabetes Age 40-65 years, BMI \>18.5 kg/m2.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Fasting glucose \> 12 mmol/l
* Hypertension: systolic \>180 mmHg and Diastolic \>110 mmHg
* Intake of more than 2 oral antidiabetic drugs or any TZD drung within 3 months before recruitment
40 Years
65 Years
ALL
Yes
Sponsors
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Rigshospitalet, Denmark
OTHER
Responsible Party
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Centre of Inflammation and Metabolism
Locations
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Centre of Inflammation and Metabolism
Copenhagen, , Denmark
Countries
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Other Identifiers
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H-4-2011-031
Identifier Type: -
Identifier Source: org_study_id
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