Evaluating Nulojix (Belatacept) Long-Term Safety in Transplant

NCT ID: NCT01386359

Last Updated: 2022-06-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

914 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-02-29

Study Completion Date

2019-04-30

Brief Summary

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To describe how Nulojix (belatacept) is used and to determine how often Post-Transplant Lymphoproliferative Disorder (PTLD), Central Nervous System (CNS) PTLD and Progressive Multifocal Leukoencephalopathy (PML), rare and serious complications of transplant treatment, occur in patients taking Nulojix (belatacept) in a real-world setting.

Detailed Description

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Time Perspective: Prospective for the majority of patients who are enrolled at the time they begin Nulojix (belatacept) treatment. Retrospective for any patients receiving Nulojix (belatacept) prior to enrollment into ENLiST Registry

Conditions

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Kidney Transplantation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

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Adult de novo EBV-seropositive kidney-transplant recipients

Adult de novo EBV-seropositive kidney-transplant recipients treated with Nulojix (belatacept)

No Intervention

Intervention Type DRUG

No Intervention. Subjects are previously treated with Nulojix (belatacept)

Interventions

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No Intervention

No Intervention. Subjects are previously treated with Nulojix (belatacept)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adult kidney transplant recipient (age ≥18 years at time of transplant)
* Kidney-only transplant recipient
* Positive EBV serostatus

a) EBV serostatus negative or unknown included per the investigator discretion
* Received first dose of Nulojix (Belatacept) within ≤ 14 days of renal transplant
* Received first dose of Nulojix (Belatacept) as part of normal clinical care (i.e. not as part of a clinical trial)

Exclusion Criteria

* Received Nulojix (belatacept) for non kidney transplants
* \<18 years of age at time of transplant
* Received first dose of Nulojix (belatacept) as an assigned study drug under a clinical trial protocol
* EBV-serostatus negative or unknown patients, except by investigator decision
* Patient who did not receive Belatacept for de novo treatment
* Recipient of concurrent or extant non-kidney organ transplant
* Received first dose of Nulojix (belatacept) \> 14 days after date of renal transplant
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Parexel

INDUSTRY

Sponsor Role collaborator

Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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University of Arizona

Tucson, Arizona, United States

Site Status

University of California, Los Angeles

Los Angeles, California, United States

Site Status

USC University Hospital

Los Angeles, California, United States

Site Status

Cedars-Sinai Med Center

Los Angeles, California, United States

Site Status

St. Vincent Medical Center - Los Angeles

Los Angeles, California, United States

Site Status

California Institute of Renal Research

San Diego, California, United States

Site Status

University of California San Francisco Medical Center

San Francisco, California, United States

Site Status

University of Colorado School of Medicine

Aurora, Colorado, United States

Site Status

Denver Nephrologists

Denver, Colorado, United States

Site Status

Yale University (Yale New Haven Hospital)

New Haven, Connecticut, United States

Site Status

Tampa General Hospital

Tampa, Florida, United States

Site Status

Emory Healthcare - Emory University Hospital (EUH)

Atlanta, Georgia, United States

Site Status

Northwestern Memorial Hospital

Chicago, Illinois, United States

Site Status

University of Illinois Mecial Center

Chicago, Illinois, United States

Site Status

University of Chicago Medical Center

Chicago, Illinois, United States

Site Status

Lutheran Kidney Transplant Center

Fort Wayne, Indiana, United States

Site Status

The Iowa Clinic

Des Moines, Iowa, United States

Site Status

Maine Medical Center

Portland, Maine, United States

Site Status

University of Maryland Medical Center

Baltimore, Maryland, United States

Site Status

Baystate Medical Center

Springfield, Massachusetts, United States

Site Status

St. Clair Nephrology Research

Detroit, Michigan, United States

Site Status

University of Minnesota Medical Center

Minneapolis, Minnesota, United States

Site Status

Barnes-Jewish Hospital

St Louis, Missouri, United States

Site Status

Bms Clinical Research Center

Does Not Exist, New Jersey, United States

Site Status

Icahn School of Medicine at Mount Sinai

New York, New York, United States

Site Status

Columbia University Medical Center

New York, New York, United States

Site Status

New York- Presbyterian/ Weill Cornell Medical Canter

New York, New York, United States

Site Status

Carolinas Medical Center

Charlotte, North Carolina, United States

Site Status

The Christ Hospital Cancer Research

Cincinnati, Ohio, United States

Site Status

Integris Baptist Medical Center

Oklahoma City, Oklahoma, United States

Site Status

Penn State Milton S. Hershey Medical Center

Hershey, Pennsylvania, United States

Site Status

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

UT Southwestern Medical Center

Dallas, Texas, United States

Site Status

Univ of Virginia HSC

Charlottesville, Virginia, United States

Site Status

Swedish Medical Center

Seattle, Washington, United States

Site Status

Medical College of Wisconsin

Milwaukee, Wisconsin, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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IM103-076

Identifier Type: -

Identifier Source: org_study_id

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