Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
150 participants
OBSERVATIONAL
2010-10-31
2015-03-31
Brief Summary
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Estradiol influences these processes by binding to estradiol receptors (ER). They are ligand-depending transcription-factors. In humans there are two subtypes: ERa and ERb, which are synthetized from gene ESR1 on chromosome 6 and ESR2 on chromosome 14. Both subtypes are expressed in the ovary. Both genes are polymorph. Especially for ERa subtype several polymorphisms and mutations are known which can be linked to breast cancer, spontaneous abortions, osteoporosis and the point in time of menarche. Furthermore some studies have shown a relationship between certain polymorphisms and the risk of infertility associated gynecological malfunctions and the result of IVF treatments.
Progesterone is a hormone which plays a crucial role in initiation and maintenance of pregnancy. It induces the transformation of the endometrium, which facilitates the implantation of the fertilized oocyte and supports the pregnancy. Progesterone acts by binding to its receptor. The gene for this receptor is polymorph within the population, whereas some variants seem to account for implantation failure of embryos.
In the investigators study the investigators will analyse the role of ERP and PRP polymorphisms in the context of IVF treatment. The analyzed genotypes are two polymorphisms of ESRI, called Pvu and Xba, as well as a variant of ESRII, ER2. In the progesterone receptor gene a single nucleotide exchange at position +331 (G-\>A) plays a role.
The parameters correlated with are concentrations of estradiol, progesterone and FSH, number of follicles, number of fertilized oocytes and pregnancy rate.
The investigators hope to optimize established treatment protocols and to improve the chances of success of IVF treatments depending on the genotype of the patient.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
Study Groups
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high responder
females with \>15 follicles or E2\>3000 after treatment with gonadotropins
No interventions assigned to this group
low responder
patients with \<3 follicles or no response to treatment with gonadotropins
No interventions assigned to this group
control
females with an indication for treatment because of male subfertility
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* reproductive age
* high response OR low response OR male subfertility
Exclusion Criteria
18 Years
40 Years
FEMALE
Yes
Sponsors
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Weill Medical College of Cornell University
OTHER
Infertility Treatment Center Dortmund
OTHER
Responsible Party
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Prof. Dr. Stefan Dieterle
Prof. Dr.
Principal Investigators
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Andreas Neuer
Role: PRINCIPAL_INVESTIGATOR
Infertility Treatment Center Dortmund
Locations
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Infertility treatment center Dortmund
Dortmund, North Rhine-Westphalia, Germany
Countries
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Other Identifiers
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PRP-ERP2010
Identifier Type: -
Identifier Source: org_study_id
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