Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

234 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-05-31

Study Completion Date

2024-05-31

Brief Summary

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Objective:

To determine the metabolic effects of the adrenalectomy in subclinical Cushing's syndrome of adrenal incidentaloma.

Methods:

234 subclinical cushing syndrome and adrenal incidentaloma will be randomly assigned into two groups(e.g adrenalectomy group and conservative treatment group).

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Detailed Description

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Conditions

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Cushing Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Adrenalectomy group

patients who undergo adrenalectomy

Group Type ACTIVE_COMPARATOR

surgery

Intervention Type PROCEDURE

adrenalectomy

Control group

patients who receive conservative treatment

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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surgery

adrenalectomy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* patients with both unilateral adrenal incidentaloma and hypercortisolism
* definition of hypercortisolism

* overnight dexamethasone suppression test, serum cortisol\>1.8ug/dL
* 24hr urine cortisol \> upper reference limit

Exclusion Criteria

* patients who took medication influencing cortisol secretion
* patients with definite clinical feature of cushing syndrome

* moon face
* abdominal striae
* skin or proximal muscle atrophy
* metabolic syndrome, hyperthyroidism, hyperparathyroidism, chronic renal failure, rheumatic disease, hematologic disease
* patients who took following medication

* insulin
* oral hypoglycemic agent
* thyroid hormone
* anti-hyperlipidemic drug
* sex hormone
* patients who taking steroid hormone or who took steroid hormone more than 2 weeks within 1 year
* psychiatric disease

Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No