The 001-DIOR Multicenter Registry

NCT ID: NCT01375465

Last Updated: 2013-09-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-02-28

Brief Summary

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The 001 DIOR study is a prospective, multicenter registry of percutaneous coronary intervention (PCI) to assess the clinical success, efficacy and safety of the Paclitaxel-eluting balloon DIOR (Eurocor GmbH, Germany) for the treatment of de novo ostial bifurcated lesions (001 of Medina classification). The DIOR balloon will be used to treat the stenotic site branch.

Detailed Description

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Conditions

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Coronary Artery Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Dior

One arm observational registry using the Dior paclitaxel eluting balloon for the treatment of de novo ostial bifurcated lesions.

Group Type OTHER

DIOR drug-eluting PTCA balloon

Intervention Type DEVICE

Treatment for 45 seconds with the DIOR balloon (3 µg/mm2 Paclitaxel concentration on balloon surface)

Interventions

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DIOR drug-eluting PTCA balloon

Treatment for 45 seconds with the DIOR balloon (3 µg/mm2 Paclitaxel concentration on balloon surface)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* De novo bifurcated lesions 001 of Medina classification, with significant stenosis only in the ostium of the side branch and a reference vessel diameter is bigger or equal 2.0mm; the DIOR balloon will be used to the treat the side branch.
* The patient has clinical evidence of myocardial ischemia (stable or unstable angina, acute and non acute myocardial infarction, silent ischemia: ECG, exercise test, etz...)
* As the maximal length of the DIORTM balloon is 30 mm, all eligible lesions should be no longer than 25 mm to ensure an adequate drug elution in the treated segment, avoiding the phenomenon of "geographical miss" .
* Target lesion(s) stenosis is more or equal 50% by visual estimation.

Exclusion Criteria

* Cardiogenic shock
* Any serious disease that might limit patient survival to less than one year
* Inability to perform clinical follow-up for a period of 1 year
* Left main bifurcation lesions: ostial left circumflex or ostial left anterior descending artery stenosis.
* Lesion length \> 25 mm
* Target vessel reference diameter \< 2mm
* Stenosis \< 50% of the reference luminal diameter
* Severe angiographic calcification at the level of the target lesion
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eurocor GmbH

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Antonio Serra, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Hospital Sant Pau, Barcelona

Beatriz Vaquerizo, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Hospital Sant Pau, Barcelona

Locations

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Hospital del Mar

Barcelona, , Spain

Site Status

Hospital Sant Pau

Barcelona, , Spain

Site Status

Hospital Trías i Pujol

Barcelona, , Spain

Site Status

Countries

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Spain

Other Identifiers

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Eur-002

Identifier Type: -

Identifier Source: org_study_id