A Single Centre Study to Compare the Efficacy and Safety of Femtosecond Laser-Assisted Versus Manual Cataract Surgery

NCT ID: NCT01373853

Last Updated: 2015-05-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

131 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-04-30

Study Completion Date

2011-12-31

Brief Summary

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This clinical study is a controlled, open, prospective, single-centre, multi-surgeon eye study to determine the safety and efficacy of intraocular cuts for femtosecond laser assisted lens frag-mentation to support phacoemulsification of the cataractous lens prior to IOL implantation. The cuts are applied by means of the FEMTEC femtosecond laser system with the CustomLens soft-ware module using a cylindrical and radial cut pattern with diameter and height dependent on anterior chamber depth, pupil diameter and ocular lens size.

The hypothesis of the study is that by means of femtosecond laser assisted lens fragmentation the required ultrasound energy used for phacoemulsification can be reduced in a safe and effective way.

Detailed Description

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Conditions

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Cataract

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Femtec Groupe A

In Group A the anterior capsulotomy and a pre-fragmentation of the ocular lens will be performed by means of femtosecond laser surgery

Group Type EXPERIMENTAL

Lens Fragmentation by means of a femtosecondlaser

Intervention Type PROCEDURE

In Group A the anterior capsulotomy and a pre-fragmentation of the ocular lens will be performed by means of femtosecond laser surgery.

Manual Group B

Group B acts as a control group where the capsulotomy and lens fragmentation are performed manually

Group Type ACTIVE_COMPARATOR

Manual Phacoemulsification

Intervention Type PROCEDURE

Group B acts as a control group where the capsulotomy and lens fragmentation are performed manually

Interventions

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Lens Fragmentation by means of a femtosecondlaser

In Group A the anterior capsulotomy and a pre-fragmentation of the ocular lens will be performed by means of femtosecond laser surgery.

Intervention Type PROCEDURE

Manual Phacoemulsification

Group B acts as a control group where the capsulotomy and lens fragmentation are performed manually

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Clear corneal media
* Patients must be at least 18 years of age.

Exclusion Criteria

* On a keratometric map of the cornea, the minimal and maximal K-values of the central 3mm zone must not differ by more than 5 dioptres. (exclusion criterium for Group A only)
* The maximum K- value may not exceed 60 D, the minimal value may not be smaller than 37 D. (exclusion criterium for Group A only)
* Corneal disease or pathology that precludes transmission of laser wavelength or distortion of laser light. (exclusion criterium for Group A only)
* Subjects with a poorly dilating pupil or other defect of the pupil that prevents the iris from adequate retraction peripherally.
* Lens/zonular instability such as, but not restricted to, Marfan's Syndrome, Pseudoexfoliation Syndrome, etc.
* Previous intraocular or corneal surgery of any kind, including any type of surgery for either refractive or therapeutic purposes in either eye.
* Known sensitivity to planned concomitant medications.
* Patients with disorders of the ocular muscle, such as nystagmus or strabismus
* Keratoconus
* Patients with woundhealing disorders such as connective tissue disease, autoimmune illnesses, immunodeficiency illnesses, ocular herpes zoster or simplex, endocrine diseases, lupus, rheumatoid arthritis
* Abnormal examination results from slit lamp, Fundus, IOL Master
* Abnormal examination results from Orbscan (exclusion criterium for Group A only)
* Patients with an autoimmune disease, collagenosis or clinically significant atopy.
* Patients who are pregnant or nursing.
* Patients who do not give informed consent.
* ACD \< 2.4 mm or ACD \> 4.5 mm as measured by ultrasonic examination (exclusion criterium for Group A only)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Technolas Perfect Vision GmbH

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Maxivision Eye Hospital

Hyderabad, Andhra Pradesh, India

Site Status

Countries

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India

Other Identifiers

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1103

Identifier Type: -

Identifier Source: org_study_id

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