Human Repeat Insult Patch Test of Wound Dressings

NCT ID: NCT01368146

Last Updated: 2025-02-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

216 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-03-31

Study Completion Date

2011-04-30

Brief Summary

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The purpose of this study is to determine whether contact sensitization occurs to the skin of normal healthy human subjects, by repetitive application of IV Clear™, Tegaderm CHG™ and Silicone Vehicle Control dressings.

Detailed Description

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A single center, within-subject randomized study design in healthy adult subjects. Qualified subjects will complete three phases of the study (induction, rest and challenge).

Data for irritation, adhesion and pain upon removal will be collected from the individual patch sites.

Conditions

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Skin Sensitization

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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IV Clear™

Group Type EXPERIMENTAL

IV Clear™

Intervention Type DEVICE

Polyurethane film with a silicone adhesive dressing containing chlorhexidine and silver

Tegaderm CHG™

Group Type ACTIVE_COMPARATOR

Tegaderm CHG™

Intervention Type DEVICE

Polyurethane film with a polyacrylate adhesive and a polyol hydrogel containing 2% w/w chlorhexidine gluconate

Control Vehicle Dressing

Group Type PLACEBO_COMPARATOR

Silicone Vehicle Control Dressing

Intervention Type DEVICE

Polyurethane film with silicone adhesive dressing, without antimicrobials

Interventions

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IV Clear™

Polyurethane film with a silicone adhesive dressing containing chlorhexidine and silver

Intervention Type DEVICE

Tegaderm CHG™

Polyurethane film with a polyacrylate adhesive and a polyol hydrogel containing 2% w/w chlorhexidine gluconate

Intervention Type DEVICE

Silicone Vehicle Control Dressing

Polyurethane film with silicone adhesive dressing, without antimicrobials

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Male or female, 18 years or older
* In good health, as determined by medical history and concomitant medication
* Able to comprehend and sign informed consent
* Unable to bear children or willing to use adequate birth control
* Willing and able to follow study directions, to participate in the study and to return for all specific visit

Exclusion Criteria

* Subject pregnant, planning a pregnancy or lactating
* Diabetes (any type)
* Mastectomy involving removal of lymph nodes
* Clinically significant skin disease, including but not limited to psoriasis, eczema, atopic dermatitis, and active cancer
* Asthma or other severe respiratory disease requiring medication
* Self-reported immunological disorders including (but not limited to) HIV positive, AIDS, rheumatoid arthritis, and systematic lupus erythematosus
* Treatment of any type of cancer within the last two years or history of skin cancer in the test area
* Use of any of the following: topically applied products (e.g. medicals, lotions, creams, etc.) at the application site within 3 days of first application of test articles, immunosuppressive drugs within 30 days of first application of test articles, systemic or topical corticosteroids within 30 days of first application of test articles, and systemic or topically applied anti-inflammatory and antihistamine medications within 3 days of first application of test articles
* Participation in any patch test for irritation or sensitization within the last four weeks
* Participation in any investigational drug study within the last four weeks
* Damaged skin in or around the test sites which includes: sunburn, extremely deep tans, uneven skin tones, tattoos, scars, excessive hair, numerous freckles, or other disfiguration
* Known sensitization to adhesives, bandages, or materials used in test articles
* Medical condition which, in investigator's judgment, makes the subject ineligible or places the subject at undue risk
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Covalon Technologies Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Micah Humphrey, B.S.

Role: PRINCIPAL_INVESTIGATOR

Hill Top Research

Locations

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Hill Top Research

St. Petersburg, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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TP-015

Identifier Type: -

Identifier Source: org_study_id

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