Evaluation of VEGF Polymorphism as Predictive Factor in Metastatic Colorectal Cancer Treated With Folfiri Plus Bevacizumab

NCT ID: NCT01363739

Last Updated: 2011-06-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

265 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-04-30

Brief Summary

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-1498C/T VEGF polymorphism, as suggested by a recent retrospective analysis, seems to have a role in predicting the efficacy of Bevacizumab plus FOLFIRI in first-line treatment of metastatic colorectal cancer patients. The present study aims to prospectively evaluate the predictive role of this polymorphism in metastatic colorectal patients receiving the same treatment.

Detailed Description

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Conditions

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Metastatic Colorectal Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Histologically confirmed colorectal adenocarcinoma;
* Measurable metastatic disease according to RECIST criteria;
* Patients receiving BV plus FOLFIRI as first-line treatment;
* Written informed consent;
* Availability of blood samples for genetic analysis.-
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Azienda Ospedaliero, Universitaria Pisana

OTHER

Sponsor Role lead

Responsible Party

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Azienda Ospedaliero, Universitaria Pisana

Locations

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Polo Oncologico Azienda Ospedaliero, Universitaria Pisana

Pisa, Pisa, Italy

Site Status RECRUITING

Countries

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Italy

Facility Contacts

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Fotios Loupakis, MD

Role: primary

050992466 ext. +39

Other Identifiers

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3108

Identifier Type: -

Identifier Source: org_study_id

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