Prevention of Photoparoxysmal Abnormalities by Mozart K448
NCT ID: NCT01363154
Last Updated: 2013-06-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
NA
10 participants
INTERVENTIONAL
2010-11-30
2013-02-28
Brief Summary
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Detailed Description
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Primary outcome will be evaluated in 3 groups, assessing alteration/cessation of photic-induced abnormalities during:
1. Treatment: music exposure to Mozart K448, vs.
2. Placebo: music exposure to Beethoven's Für Elise for piano, vs.
3. Control: no music exposure.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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Mozart K448
Treatment: music exposure to Mozart K448
Mozart K448
Subjects will receive auditory stimulation by exposure to Mozart's Sonata for Two Pianos in D Major, K448.
Beethoven's Für Elise
Placebo: music exposure to Beethoven's Für Elise for piano
Beethoven's Für Elise
Subjects will receive auditory stimulation by exposure to Beethoven's Für Elise.
No music exposure
Subject's will not receive an intervention and will therefore, not receive auditory stimulation and/or exposure to music.
No music exposure
Control: no music exposure
No interventions assigned to this group
Interventions
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Mozart K448
Subjects will receive auditory stimulation by exposure to Mozart's Sonata for Two Pianos in D Major, K448.
Beethoven's Für Elise
Subjects will receive auditory stimulation by exposure to Beethoven's Für Elise.
No music exposure
Subject's will not receive an intervention and will therefore, not receive auditory stimulation and/or exposure to music.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Female or male with photoparoxysmal epilepsy clinical history, and at least one seizure, as defined by the International League Against Epilepsy (International Classification of Epilepsies and Epileptic Syndromes; Commission on Classification and Terminology of the International League Against Epilepsy 1989)
* Abnormal EEG consistent with features of photoparoxysmal epilepsy: occipital based epileptiform abnormalities with otherwise normal background interictal EEG;
* On \< or equal to 2 anti-seizure medications \[range 0-2 AEDs\]
Exclusion Criteria
* Inability to complete and/or comply with study protocol
5 Years
17 Years
ALL
No
Sponsors
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Medical University of South Carolina
OTHER
Responsible Party
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Robert P. Turner
Assoc Prof Neurosciences
Principal Investigators
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Robert P Turner, MD, MSCR
Role: PRINCIPAL_INVESTIGATOR
Medical University of South Carolina
Mark Bodner, MD
Role: PRINCIPAL_INVESTIGATOR
MIND Institute
Lee Anne Tetrick, BS
Role: STUDY_DIRECTOR
Medical University of South Carolina
Locations
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Medical University of South Carolina
Charleston, South Carolina, United States
Countries
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References
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Banerjee PN, Filippi D, Allen Hauser W. The descriptive epidemiology of epilepsy-a review. Epilepsy Res. 2009 Jul;85(1):31-45. doi: 10.1016/j.eplepsyres.2009.03.003. Epub 2009 Apr 15.
Bodner M, Muftuler LT, Nalcioglu O, Shaw GL. FMRI study relevant to the Mozart effect: brain areas involved in spatial-temporal reasoning. Neurol Res. 2001 Oct;23(7):683-90. doi: 10.1179/016164101101199108.
Davis R, Emmonds SE. Cerebellar stimulation for seizure control: 17-year study. Stereotact Funct Neurosurg. 1992;58(1-4):200-8. doi: 10.1159/000098996.
Engel J Jr; International League Against Epilepsy (ILAE). A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia. 2001 Jun;42(6):796-803. doi: 10.1046/j.1528-1157.2001.10401.x. No abstract available.
Fisher RS, Uematsu S, Krauss GL, Cysyk BJ, McPherson R, Lesser RP, Gordon B, Schwerdt P, Rise M. Placebo-controlled pilot study of centromedian thalamic stimulation in treatment of intractable seizures. Epilepsia. 1992 Sep-Oct;33(5):841-51. doi: 10.1111/j.1528-1157.1992.tb02192.x.
Fisher RS, Harding G, Erba G, Barkley GL, Wilkins A; Epilepsy Foundation of America Working Group. Photic- and pattern-induced seizures: a review for the Epilepsy Foundation of America Working Group. Epilepsia. 2005 Sep;46(9):1426-41. doi: 10.1111/j.1528-1167.2005.31405.x.
Hughes JR, Daaboul Y, Fino JJ, Shaw GL. The "Mozart effect" on epileptiform activity. Clin Electroencephalogr. 1998 Jul;29(3):109-19. doi: 10.1177/155005949802900301.
Hughes JR, Fino JJ, Melyn MA. Is there a chronic change of the "Mozart effect" on epileptiform activity? A case study. Clin Electroencephalogr. 1999 Apr;30(2):44-5. doi: 10.1177/155005949903000204.
Hughes JR. The Mozart Effect. Epilepsy Behav. 2001 Oct;2(5):396-417. doi: 10.1006/ebeh.2001.0250.
Hughes JR. The Mozart Effect: Additional Data. Epilepsy Behav. 2002 Apr;3(2):182-184. doi: 10.1006/ebeh.2002.0329.
Jacobs MP, Fischbach GD, Davis MR, Dichter MA, Dingledine R, Lowenstein DH, Morrell MJ, Noebels JL, Rogawski MA, Spencer SS, Theodore WH. Future directions for epilepsy research. Neurology. 2001 Nov 13;57(9):1536-42. doi: 10.1212/wnl.57.9.1536.
Lahiri N, Duncan JS. The Mozart effect: encore. Epilepsy Behav. 2007 Aug;11(1):152-3. doi: 10.1016/j.yebeh.2007.04.017. Epub 2007 Jun 29.
Macdonell RA, Curatolo JM, Berkovic SF. Transcranial magnetic stimulation and epilepsy. J Clin Neurophysiol. 2002 Aug;19(4):294-306. doi: 10.1097/00004691-200208000-00004.
Kasteleijn-Nolst Trenite DG, Binnie CD, Harding GF, Wilkins A. Photic stimulation: standardization of screening methods. Epilepsia. 1999;40 Suppl 4:75-9. doi: 10.1111/j.1528-1157.1999.tb00911.x.
Kasteleijn-Nolst Trenite DG, van der Beld G, Heynderickx I, Groen P. Visual stimuli in daily life. Epilepsia. 2004;45 Suppl 1:2-6. doi: 10.1111/j.0013-9580.2004.451004.x.
Sarnthein J, vonStein A, Rappelsberger P, Petsche H, Rauscher FH, Shaw GL. Persistent patterns of brain activity: an EEG coherence study of the positive effect of music on spatial-temporal reasoning. Neurol Res. 1997 Apr;19(2):107-16. doi: 10.1080/01616412.1997.11740782.
Thornton-Wells TA, Cannistraci CJ, Anderson AW, Kim CY, Eapen M, Gore JC, Blake R, Dykens EM. Auditory attraction: activation of visual cortex by music and sound in Williams syndrome. Am J Intellect Dev Disabil. 2010 Mar;115(2):172-89. doi: 10.1352/1944-7588-115.172.
Turner RP. The acute effect of music on interictal epileptiform discharges. Epilepsy Behav. 2004 Oct;5(5):662-8. doi: 10.1016/j.yebeh.2004.07.003.
Van Buren JM, Wood JH, Oakley J, Hambrecht F. Preliminary evaluation of cerebellar stimulation by double-blind stimulation and biological criteria in the treatment of epilepsy. J Neurosurg. 1978 Mar;48(3):407-16. doi: 10.3171/jns.1978.48.3.0407. No abstract available.
Verduzco-Flores S, Ermentrout B, Bodner M. From working memory to epilepsy: dynamics of facilitation and inhibition in a cortical network. Chaos. 2009 Mar;19(1):015115. doi: 10.1063/1.3080663.
Bodner M, Turner RP, Bowers C, Norment C (2009) Patterned auditory stimulus reduces seizure frequency in neurologically-impaired individuals. (submitted May 2010 to Epilepsia for publication)
CURE: Citizens United for Research in Epilepsy. Web. 04 Oct. 2010. <http://www.cureepilepsy.org/home.asp>.
Epilepsy Foundation of America. Web. 04 Oct. 2010. <https://efa.org/>.
Franaszczuk PJ, Kudela P, Bergey GK. External excitatory stimuli can terminate bursting in neural network models. Epilepsy Res. 2003 Feb;53(1-2):65-80. doi: 10.1016/s0920-1211(02)00248-6.
Harding GF, Jeavons PM. Photosensitive Epilepsy. MacKeith Press, London, 1994.
Temkin O. The falling sickness: A history of epilepsy from the Greeks to the beginnings of modern neurology. Baltimore: Johns Hopkins University Press, 1971.
Turner RP, Bodner M, Wang L, Norment C, Bowers C, Zhou Y. The anti-epileptiform effect of acute auditory stimulation on Rolandic spikes: EEG spectral analysis and coherence in patients with Rolandic epilepsy. (2010 in preparation)
ILAE: International League Against Epilepsy. Web. 02 Oct. 2010. <http://www.ilae-epilepsy.org/>.
Zifkin BG and Andermann F. Visual Sensitive Epilepsies. International League Against Epilepsy. 28 Feb. 2005. Web. 04 Oct. 2010. <http://www.ilae-epilepsy.org/>.
Other Identifiers
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7683
Identifier Type: -
Identifier Source: org_study_id
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