Effect of 10mg Domperidone on Gastric Emptying of a High-fat Meal and Appetite Sensations in Healthy Adults
NCT ID: NCT01347814
Last Updated: 2011-05-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
13 participants
INTERVENTIONAL
2008-02-29
2010-04-30
Brief Summary
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Detailed Description
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The effect of acute oral administration of 10 mg domperidone on gastric emptying of a high-fat pancake test meal, and subjective appetite sensations by visual analogue scale will be measured for six hours postprandially in a randomized, placebo-controlled, single-blinded manner in 13 healthy subjects.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
SINGLE
Interventions
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Domperidone 10mg
10mg domperidone tablet 30 minutes before a test-meal.
Placebo
Homeopathic (Sugar) pill-Placebo
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
10 Years
40 Years
ALL
Yes
Sponsors
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Irish Research Council
OTHER
University of Limerick
OTHER
Responsible Party
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University of Limerick
Principal Investigators
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Amir Shafat
Role: PRINCIPAL_INVESTIGATOR
University of Limerick
Locations
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Department of Physical Education & Sport Sciences, University of Limerick
Limerick, , Ireland
Countries
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References
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Reddymasu SC, Soykan I, McCallum RW. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007 Sep;102(9):2036-45. doi: 10.1111/j.1572-0241.2007.01255.x. Epub 2007 May 3.
Markey O, Shafat A. Does domperidone, a D2-antagonist alter gastric emptying rates and appetite sensations in healthy adults with high-fat meal? A block-randomised, single-blind placebo-controlled study. Ir J Med Sci. 2012 Jun;181(2):215-9. doi: 10.1007/s11845-011-0785-2. Epub 2011 Nov 29.
Other Identifiers
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DompGastEmpt
Identifier Type: -
Identifier Source: org_study_id
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