Comparative Trial Of Maraviroc Versus Emtricitabine/Tenofovir Both With Darunavir/Ritonavir In Antiretroviral-Naive Patients Infected With CCR5 Tropic HIV 1

NCT ID: NCT01345630

Last Updated: 2016-01-14

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

813 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-09-30

Study Completion Date

2014-01-31

Brief Summary

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The purpose of this study is to assess whether maraviroc administered once daily is non-inferior to emtricitabine/tenofovir also administered once daily each in combination with darunavir/ritonavir in the treatment of antiretroviral-naive patients as evaluated at Week 48 of treatment.

Detailed Description

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The study was terminated on October 8, 2013 following a preliminary review of the Week 48 primary efficacy data by the study's external independent Data Monitoring Committee (DMC). The DMC assessed the data as demonstrating significant differences between the treatment arms in virologic responses and failures. The DMC recommended and the Sponsor concurred that the study be terminated because of the inferior efficacy of the Maraviroc arm as compared to the comparator arm (Emtricitabine/Tenofovir).

Conditions

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HIV-1

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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Maraviroc

Maraviroc 150 mg once daily plus darunavir/ritonavir 800/100 mg once daily plus placebo for emtricitabine/tenofovir once daily.

Group Type EXPERIMENTAL

Maraviroc

Intervention Type DRUG

Maraviroc tablet 150 mg once daily for 96 weeks.

darunavir/ritonavir 800/100 mg

Intervention Type DRUG

darunavir/ritonavir 800/100 mg

placebo for maraviroc

Intervention Type DRUG

placebo for maraviroc

Emtricitabine/tenofovir

Emtricitabine/tenofovir 200/300 mg once daily plus darunavir/ritonavir 800/100 mg once daily plus placebo for maraviroc once daily.

Group Type ACTIVE_COMPARATOR

Emtricitabine/tenofovir

Intervention Type DRUG

Emtricitabine/tenofovir tablet 200/300 mg once daily for 96 weeks.

placebo for emtricitabine/tenofovir

Intervention Type DRUG

placebo for emtricitabine/tenofovir

Interventions

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Maraviroc

Maraviroc tablet 150 mg once daily for 96 weeks.

Intervention Type DRUG

Emtricitabine/tenofovir

Emtricitabine/tenofovir tablet 200/300 mg once daily for 96 weeks.

Intervention Type DRUG

darunavir/ritonavir 800/100 mg

darunavir/ritonavir 800/100 mg

Intervention Type DRUG

placebo for emtricitabine/tenofovir

placebo for emtricitabine/tenofovir

Intervention Type DRUG

placebo for maraviroc

placebo for maraviroc

Intervention Type DRUG

Other Intervention Names

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Selzentry, Celsentri Truvada Truvada Selzentry, Celsentri

Eligibility Criteria

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Inclusion Criteria

* Plasma HIV-1 RNA equal to or greater than 1,000 copies/mL measured at the Screening Visit.
* CD4 count equal to or greater than 100 cells/mm3 at Screening.
* Have only R5 HIV 1 at Screening as verified by a randomized tropism assay.

Exclusion Criteria

* Prior treatment with any other HIV antiretroviral therapy for more than 14 days at any time.
* Any evidence of genotypic/phenotypic resistance to darunavir, tenofovir, and emtricitabine.
* CXCR4 using virus detected using randomized tropism determination or repeated failure to obtain an interpretable tropism result.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role collaborator

ViiV Healthcare

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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University of Alabama at Birmingham - 1917 Research Clinic

Birmingham, Alabama, United States

Site Status

Health Services Center

Hobson City, Alabama, United States

Site Status

Kaiser Permanente

Hayward, California, United States

Site Status

Cedars-Sinai Medical Center

Los Angeles, California, United States

Site Status

Dr. Anthony Mills, MD, Inc.

Los Angeles, California, United States

Site Status

Orange Coast Medical Group

Newport Beach, California, United States

Site Status

Desert Oasis Healthcare Medical Group

Palm Springs, California, United States

Site Status

University of California Davis Research

Sacramento, California, United States

Site Status

TICON I Research Clinic (DEXA Scan only)

Sacramento, California, United States

Site Status

Kaiser Hospital Sacramento

Sacramento, California, United States

Site Status

Synarc Inc.

San Francisco, California, United States

Site Status

Investigational Drugs Pharmacy

San Francisco, California, United States

Site Status

Kaiser Permanente - Clinical Trials Unit

San Francisco, California, United States

Site Status

Kaiser Permanente Santa Clara

Santa Clara, California, United States

Site Status

Kaiser Permanente

Union City, California, United States

Site Status

University of Colorado Denver - University of Colorado Hospital

Aurora, Colorado, United States

Site Status

Kaiser Permanente of Colorado

Denver, Colorado, United States

Site Status

Yale - New Haven Hospital Nathan Smith Clinic

New Haven, Connecticut, United States

Site Status

Yale University

New Haven, Connecticut, United States

Site Status

Circle CARE Center

Norwalk, Connecticut, United States

Site Status

Capital Medical Associates, PC

Washington D.C., District of Columbia, United States

Site Status

George Washington University Medical Faculty Associates

Washington D.C., District of Columbia, United States

Site Status

Broward Health - Comprehensive Care Center

Fort Lauderdale, Florida, United States

Site Status

Broward General Medical Center

Fort Lauderdale, Florida, United States

Site Status

The Kinder Medical Group

Miami, Florida, United States

Site Status

UMHC/Sylvester Comprehensive Cancer Center

Miami, Florida, United States

Site Status

University of Miami AIDS Clinical Research Unit

Miami, Florida, United States

Site Status

University of Miami

Miami, Florida, United States

Site Status

Community AIDS Resource Inc dba Care Resource

Miami, Florida, United States

Site Status

Miami Research Associates

Miami, Florida, United States

Site Status

Wohlfeiler, Piperato and Associates, LLC

Miami Beach, Florida, United States

Site Status

Infectious Diseases Associates of Northwest Florida, PA

Pensacola, Florida, United States

Site Status

St. Joseph's Hospital Diagnostic Center

Tampa, Florida, United States

Site Status

University of South Florida Health-HIV Clinical Research Unit

Tampa, Florida, United States

Site Status

Infectious Disease Research Institute, Inc.

Tampa, Florida, United States

Site Status

Osteoporosis Care Center

Tampa, Florida, United States

Site Status

Quest Diagnostic Laboratory

Tampa, Florida, United States

Site Status

Rowan Tree Medical, PA

Wilton Manors, Florida, United States

Site Status

AIDS Research Consortium of Atlanta

Atlanta, Georgia, United States

Site Status

DeKalb Medical Diagnostic Breast Center

Decatur, Georgia, United States

Site Status

Infectious Disease Specialists of Atlanta

Decatur, Georgia, United States

Site Status

Northwestern University/NMH

Chicago, Illinois, United States

Site Status

Northwestern University

Chicago, Illinois, United States

Site Status

Howard Brown Health Center

Chicago, Illinois, United States

Site Status

University of Iowa, University of Hospitals and Clinics - Division of Infectious Disease

Iowa City, Iowa, United States

Site Status

Tulane University School of Medicine

New Orleans, Louisiana, United States

Site Status

Ochsner Clinic Foundation

New Orleans, Louisiana, United States

Site Status

Baystate Infectious Diseases Clinical Research

Springfield, Massachusetts, United States

Site Status

Be Well Medical Center, PC

Berkley, Michigan, United States

Site Status

University Physicians Group

Detroit, Michigan, United States

Site Status

Wayne State University

Detroit, Michigan, United States

Site Status

Henry Ford Health System

Detroit, Michigan, United States

Site Status

Michigan State University College of Osteopathic Medicine - Department of Internal Medicine

East Lansing, Michigan, United States

Site Status

Biomedical and Health Institutional Review Board

East Lansing, Michigan, United States

Site Status

Ingham County Health Department

Lansing, Michigan, United States

Site Status

Hennepin County Medical Center

Minneapolis, Minnesota, United States

Site Status

Kansas City Free Health Clinic

Kansas City, Missouri, United States

Site Status

University of Nebraska Medical Center

Omaha, Nebraska, United States

Site Status

Jersey Shore University Medical Center

Neptune City, New Jersey, United States

Site Status

Brandywine Common

Neptune City, New Jersey, United States

Site Status

Jersey Shore University Medical Center

Neptune City, New Jersey, United States

Site Status

Saint Michael's Medical Center

Newark, New Jersey, United States

Site Status

Erie County Medical Center

Buffalo, New York, United States

Site Status

Beth Israel Medical Center - AIDS Clinical Trials Unit

New York, New York, United States

Site Status

AIDS Community Research Initiative of America (ACRIA)

New York, New York, United States

Site Status

Research Across America

New York, New York, United States

Site Status

Dr. Howard A. Grossman, M.D.

New York, New York, United States

Site Status

AIDS Care

Rochester, New York, United States

Site Status

New York Medical College

Valhalla, New York, United States

Site Status

I.D. Consultants, P.A.

Charlotte, North Carolina, United States

Site Status

(DEXA Scan Facility) East Carolina University Brody Outpatient Center

Greenville, North Carolina, United States

Site Status

East Carolina University Division of Infectious Diseases

Greenville, North Carolina, United States

Site Status

University of Cincinnati - Department of Internal Medicine

Cincinnati, Ohio, United States

Site Status

The University of Toledo Medical Center

Toledo, Ohio, United States

Site Status

Central Texas Clinical Research

Austin, Texas, United States

Site Status

Dallas Diabetes and Endocrine Center

Dallas, Texas, United States

Site Status

Parkland Memorial Hospital

Dallas, Texas, United States

Site Status

University of Texas Southwestern Medical Center at Dallas

Dallas, Texas, United States

Site Status

North Texas Infectious Diseases Consultants, PA

Dallas, Texas, United States

Site Status

Therapeutic Concepts, PA

Houston, Texas, United States

Site Status

Research Access Network

Houston, Texas, United States

Site Status

The Office of Dr. Gordon E. Crofoot, M.D., PA

Houston, Texas, United States

Site Status

Swedish Medical Center

Seattle, Washington, United States

Site Status

Swedish Medical Center

Seattle, Washington, United States

Site Status

East Sydney Doctors

Darlinghurst, New South Wales, Australia

Site Status

Holdsworth House General Practice

Darlinghurst, New South Wales, Australia

Site Status

St Vincent's Hospital

Darlinghurst, New South Wales, Australia

Site Status

Taylor Square Private Clinic

Surry Hills, New South Wales, Australia

Site Status

Brisbane Sexual Health and HIV Service

Brisbane, Queensland, Australia

Site Status

Melbourne Sexual Health Centre

Carlton, Victoria, Australia

Site Status

Clinical Research Unit, Infectious Diseases

Melbourne, Victoria, Australia

Site Status

AKH Wien Universitaetsklinik fuer Dermatologie

Vienna, , Austria

Site Status

Instituut voor Tropische Geneeskunde

Antwerp, , Belgium

Site Status

C.H.U. St-Pierre

Brussels, , Belgium

Site Status

Hôpital Universitaire Erasme

Brussels, , Belgium

Site Status

Cliniques Universitaires St-Luc

Brussels, , Belgium

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Universitair Ziekenhuis Gent

Ghent, , Belgium

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C.H.U. Sart-Tilman

Liège, , Belgium

Site Status

Vancouver ID Research and Care Centre Society

Vancouver, British Columbia, Canada

Site Status

The Ottawa Hospital-Riverside Campus

Ottawa, Ontario, Canada

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The Ottawa Hospital

Ottawa, Ontario, Canada

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Maple Leaf Research / Maple Leaf Medical Clinic

Toronto, Ontario, Canada

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University Health Network / Toronto General Hospital

Toronto, Ontario, Canada

Site Status

Clinique Medicale L'Actuel

Montreal, Quebec, Canada

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Clinique Medicale du Quartier Latin

Montreal, Quebec, Canada

Site Status

Hvidovre Hospital, Infektionsmedicinsk afd.

Hvidovre, , Denmark

Site Status

Rigshospitalet, Epidemiklinikken

Koebenhavn OE, , Denmark

Site Status

Odense Universitetshospital

Odense, , Denmark

Site Status

Infektiosairauksien poliklinikka,HUS Auroran sairaala, rakennus 5, 1. krs

Helsinki, , Finland

Site Status

CHR d'Orleans la Source

Orléans, Cedex 02, France

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Hopital Saint Antoine

Paris, Cedex 12, France

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Hopital Bichat

Paris, Cedex 18, France

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Hopital Saint-andre

Bordeaux, France, France

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Hopital Henri Mondor

Créteil, , France

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Hopital Bicetre

Le Kremlin-Bicêtre, , France

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Hopital de la Croix Rousse

Lyon, , France

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Hopital Gui de Chauliac

Montpellier, , France

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CHU de Nantes - Hotel Dieu

Nantes, , France

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Hôpital de la Pitié Salpétrière

Paris, , France

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Hopital Tenon, Service des Maladies Infectieuses

Paris, , France

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Hopital Saint-Louis

Paris, , France

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Nouvel Hopital Civil

Strasbourg, , France

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Centre Hospitalier de Tourcoing

Tourcoing, , France

Site Status

Praxis Christiane Cordes

Berlin, , Germany

Site Status

Studiengesellschaft mbH Gubener 37

Berlin, , Germany

Site Status

EPIMED - Gesellschaft fuer epidemiologische und klinische Forschung in der Medizin mbH

Berlin, , Germany

Site Status

Universitaetsklinikum Bonn, Immunologische Ambulanz HIV

Bonn, , Germany

Site Status

Klinikum der Universitaet zu Koeln, Klinik I fuer Innere Medizin

Cologne, , Germany

Site Status

Klinikum der J.W. Goethe-Universitaet, Medizinische Klinik II

Frankfurt am Main, , Germany

Site Status

InfektioResearch GmbH & Co. KG

Frankfurt am Main, , Germany

Site Status

ifi - Studien und Projekte GmbH

Hamburg, , Germany

Site Status

ICH - Study - Center GmbH & Co. KG

Hamburg, , Germany

Site Status

Universitaetsklinikum Hamburg-Eppendorf

Hamburg, , Germany

Site Status

MUC Research Group GbR

München, , Germany

Site Status

Ludwig-Maximilians-Universitaet, Medizinische Poliklinik - Klinikum Innenstadt

München, , Germany

Site Status

Egyesitett Szent Istvan és Szent Laszlo Korhaz-Rendelointezet

Budapest, , Hungary

Site Status

Ospedale San Raffaele

Milan, , Italy

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University Medical Center Utrecht

Utrecht, , Netherlands

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Wojewodzki Szpital Obserwacyjno - Zakazny im. Tadeusza Browicza

Bydgoszcz, , Poland

Site Status

SPZOZ Wojewodzki Szpital Zakazny

Warsaw, , Poland

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EMC Instytut Medyczny S.A. Przychodnia przy ul. Lowieckiej

Wroclaw, , Poland

Site Status

Hospital Prof. Doutor Fernando Fonseca E.P.E.

Amadora, Portugal, Portugal

Site Status

Centro Hospitalar de Lisboa - Zona Central - Hospital Santo António Capuchos

Lisbon, , Portugal

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Hospital Sta. Maria

Lisbon, , Portugal

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Hospital São João

Porto, , Portugal

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Innovative Care PSC

Bayamón, PR, Puerto Rico

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Ararat Research Center

Ponce, PR, Puerto Rico

Site Status

Medical Center University Hospital

Rio Piedras, PR, Puerto Rico

Site Status

Clinical Research Puerto Rico

San Juan, PR, Puerto Rico

Site Status

HOPE Clinical Research

San Juan, PR, Puerto Rico

Site Status

University of Puerto Rico Medical Sciences Campus

Rio Piedras, , Puerto Rico

Site Status

Hospital General Universitario de Alicante

Alicante, Alicante, Spain

Site Status

Hospital del Mar

Barcelona, Barcelona, Spain

Site Status

Hospital de la Santa Creu i Sant Pau

Barcelona, Barcelona, Spain

Site Status

Hospital Clinic I Provincial de Barcelona

Barcelona, Barcelona, Spain

Site Status

Hospital Universitari de Bellvitge

L'Hospitalet de Llobregat, Barcelona, Spain

Site Status

Hospital Universitario Reina Sofia - Hospital Provincial

Córdoba, Cordoba, Spain

Site Status

Hospital General Universitario Gregorio Marañon

Madrid, Madrid, Spain

Site Status

Hospital Universitario de La Paz

Madrid, Madrid, Spain

Site Status

Hospital Universitario Virgen de la Macarena

Seville, Sevilla, Spain

Site Status

SU Ostra sjukhuset, Infektionsmottagningen

Gothenburg, , Sweden

Site Status

Skanes Universitetssjukhus

Malmo, , Sweden

Site Status

Sodersjukhuset, Venhalsan

Stockholm, , Sweden

Site Status

Karolinska Universitetssjukhuset Huddinge

Stockholm, , Sweden

Site Status

Universitaetsspital Basel Infektiologie und Spitalhygiene

Basel, , Switzerland

Site Status

Inselspital Universitaetsklinik fuer Infektiologie

Bern, , Switzerland

Site Status

Kantonsspital St. Gallen

Sankt Gallen, , Switzerland

Site Status

Universitatsspital Zurich

Zurich, , Switzerland

Site Status

Dept of Sexual Health & HIV Medicine

Birmingham, , United Kingdom

Site Status

HIV Research Department, Elton John Centre

Brighton, , United Kingdom

Site Status

Regional Infectious Diseases Unit

Edinburgh, , United Kingdom

Site Status

Grahame Hayton Unit, Ambrose King Centre, Royal London Hospital,

London, , United Kingdom

Site Status

Ian Charleson Day Centre, Royal Free Hospital

London, , United Kingdom

Site Status

Queen Elizabeth Hospital

London, , United Kingdom

Site Status

St Stephen's Centre, Chelsea and Westminster Hospital NHS Foundation Trust

London, , United Kingdom

Site Status

Centre for Sexual Health & HIV Research, University College London

London, , United Kingdom

Site Status

Department of Infectious Diseases & Tropical Medicine, Pennine Acute Trust Hospitals

Manchester, , United Kingdom

Site Status

Countries

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United States Australia Austria Belgium Canada Denmark Finland France Germany Hungary Italy Netherlands Poland Portugal Puerto Rico Spain Sweden Switzerland United Kingdom

Related Links

Other Identifiers

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2010-021785-30

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

A4001095

Identifier Type: -

Identifier Source: org_study_id

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