Effect of Metformin on Decrement in Levothyroxin Dose Required for Thyroid Stimulating Hormone (TSH) Suppression in Patients With Differentiated Thyroid Cancer
NCT ID: NCT01341886
Last Updated: 2011-04-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
51 participants
INTERVENTIONAL
2010-04-30
2011-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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metformin
patients who receive metformin in addition to levothyroxine
Metformin
in case group metformin is added to levothyroxine and levothyroxine is decreased by 30% .in control group levothyroxine is reduced by 30% and no metformin is added to the regimen.
levothyroxine
patients who receive only levothyroxine
Metformin
in case group metformin is added to levothyroxine and levothyroxine is decreased by 30% .in control group levothyroxine is reduced by 30% and no metformin is added to the regimen.
Interventions
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Metformin
in case group metformin is added to levothyroxine and levothyroxine is decreased by 30% .in control group levothyroxine is reduced by 30% and no metformin is added to the regimen.
Eligibility Criteria
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Inclusion Criteria
* stage 1 or 2 according to TNM system version 6
* surgery and radioiodine treatment
* levothyroxine suppression treatment
Exclusion Criteria
* liver failure
* renal failure
* pregnancy
* drugs (colestyramin, sucralfate, phenobarbital, phenytoin, carbamazepin, rifampin, amiodarone, chloroquin, androgens, sertraline, frusemide, heparin)
80 Years
ALL
No
Sponsors
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Mashhad University of Medical Sciences
OTHER
Responsible Party
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endocrine research center
Locations
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Mashad University of Medical Sciences
Mashhad, Khorasan Razavi, Iran
Countries
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Other Identifiers
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METTC
Identifier Type: -
Identifier Source: org_study_id
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