Level of Expression and Prognostic Value of CXCL4, CXCL4L1 and CXCR3 in Renal Cell Carcinoma
NCT ID: NCT01339975
Last Updated: 2019-08-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
310 participants
OBSERVATIONAL
2011-06-06
2019-05-31
Brief Summary
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The aim of this study is to evaluate the interest of CXCL4, CXCL4L1 and CXCR3 as biomarkers in localized, locally advanced or metastatic RCC. Indeed these chemokines have shown anti-angiogenic and anti-tumor properties in experimental models and may be particularly interesting for prognostic and predictive purposes.
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Detailed Description
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Therefore the identification of new molecular biomarkers is important:
* to improve the precision of prognostic models currently based on clinical, biological or histopathological variables
* to identify high risk patients that could benefit from an adjuvant treatment or a closer postoperative follow-up
* to predict the response to antiangiogenic therapies and therefore identify the drug which is likely to be the most effective within an ever increasing pharmacopeia
* to follow the therapy as precisely as possible, predict or attest the disease progression justifying a therapeutic modification
Low CXCL4, CXCL4L1 and CXCR3 tumor expression levels are associated with bad prognosis factors in RCC. Consequently their interest in RCC is worth being evaluated, in two subgroups : Localized / locally advanced renal cell carcinoma and Metastatic renal cell carcinoma.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Group A. Surgically treated patients
Patients having a radical or partial nephrectomy.
Biological sample
2 blood samples of 10mL + one urine sample
* on pre-operative d-1/d, post-operative d1 and d5(+/-2),
* one month post-operative,
* at the end of the study in the absence of disease progression or at the date of recurrence or progression if the case arises.
Group B. Patients treated with targeted therapies
Patients treated by RCC-directed targeted therapy
Biological sample
2 blood samples of 10mL + one urine sample
* before starting the therapy
* at first therapeutic evaluation (2 or 3 months depending on the treatment chosen)
* at the end of the study or at the date of disease progression.
Interventions
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Biological sample
2 blood samples of 10mL + one urine sample
* on pre-operative d-1/d, post-operative d1 and d5(+/-2),
* one month post-operative,
* at the end of the study in the absence of disease progression or at the date of recurrence or progression if the case arises.
Biological sample
2 blood samples of 10mL + one urine sample
* before starting the therapy
* at first therapeutic evaluation (2 or 3 months depending on the treatment chosen)
* at the end of the study or at the date of disease progression.
Eligibility Criteria
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Inclusion Criteria
* having a radical or partial nephrectomy
* or treated by RCC-directed targeted therapy
* Patients who have signed and dated an informed consent form with the investigator
Exclusion Criteria
18 Years
ALL
No
Sponsors
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University Hospital, Bordeaux
OTHER
Responsible Party
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Principal Investigators
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Jean-Christophe BERNHARD, Dr
Role: PRINCIPAL_INVESTIGATOR
University Hospital Bordeaux, France
Locations
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University Bordeaux Hospital
Bordeaux, , France
Countries
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References
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Other Identifiers
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CHUBX 2010/45
Identifier Type: -
Identifier Source: org_study_id
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