Safety and Efficacy Study of Dysport RU and Glabellar Lines

NCT ID: NCT01333397

Last Updated: 2022-09-27

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

176 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-03-31

Study Completion Date

2011-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The primary objective is to assess the dose response versus placebo of a single treatment of Dysport RU (Dysport RU, Ready to Use, for injection), for the improvement in appearance of moderate to severe glabellar lines at maximum frown.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Glabellar Frown Lines

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Dysport RU 20 U

Group Type EXPERIMENTAL

Botulinum toxin type A

Intervention Type BIOLOGICAL

I.M. (in the muscle) injection on day 1 (single treatment cycle)

Dysport RU 50 U

Group Type EXPERIMENTAL

Botulinum toxin type A

Intervention Type BIOLOGICAL

I.M. (in the muscle) injection on day 1 (single treatment cycle)

Dysport RU 75 U

Group Type EXPERIMENTAL

Botulinum toxin type A

Intervention Type BIOLOGICAL

I.M. (in the muscle) injection on day 1 (single treatment cycle)

Dysport (Azzalure) 50 U

Group Type ACTIVE_COMPARATOR

Botulinum toxin type A

Intervention Type BIOLOGICAL

I.M. on day 1 (single treatment cycle)

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

I.M. on day 1 (single treatment cycle)

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Botulinum toxin type A

I.M. (in the muscle) injection on day 1 (single treatment cycle)

Intervention Type BIOLOGICAL

Botulinum toxin type A

I.M. on day 1 (single treatment cycle)

Intervention Type BIOLOGICAL

Placebo

I.M. on day 1 (single treatment cycle)

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

AbobotulinumtoxinA (DysportRU®) AbobotulinumtoxinA (Azzalure®)

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Female between 30 - 60 years of age
* Moderate to severe vertical glabellar lines at maximum frown at baseline

Exclusion Criteria

* Silicone injections into the upper face
* Any prior treatment with fillers (e.g. collagen-type implants) skin abrasions or photorejuvenation within the previous 12 months
* Any planned facial cosmetic surgery during the study period
* A history of ablative skin resurfacing of the area to be treated during the study.
Minimum Eligible Age

30 Years

Maximum Eligible Age

60 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Ipsen

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Ipsen Study Director

Role: STUDY_DIRECTOR

Ipsen

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Private practice

Bordeaux, , France

Site Status

Private practice

Cannes, , France

Site Status

Private practice

Juan-les-Pins, , France

Site Status

Private practice

Paris, , France

Site Status

Charité hospital

Berlin, , Germany

Site Status

Private clinic

Dresden, , Germany

Site Status

Private clinic

Munich, , Germany

Site Status

Private clinic

Starnberg, , Germany

Site Status

Countries

Review the countries where the study has at least one active or historical site.

France Germany

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2010-019085-82

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

Y-52-52120-146

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Brow Lifting With Dysport
NCT01401803 COMPLETED PHASE4