Comparing the Efficacy and Safety of NN1250 Once Daily When Titrated Using 2 Different Algorithms in Insulin naïve Subjects With Type 2 Diabetes Mellitus

NCT ID: NCT01326026

Last Updated: 2017-03-06

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

222 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-03-31

Study Completion Date

2011-12-31

Brief Summary

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This trial is conducted in Europe and the United States of America (USA). The aim of this trial is to compare the efficacy and safety of NN1250 (insulin degludec (IDeg)) once daily in insulin naïve subjects with type 2 diabetes mellitus when titrated using two different self-titration algorithms (dose individually adjusted) in combination with metformin.

Detailed Description

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Conditions

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Diabetes Diabetes Mellitus, Type 2

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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IDeg Simple

Group Type EXPERIMENTAL

insulin degludec

Intervention Type DRUG

Injected subcutaneously (under the skin) once daily. Dose individually adjusted.

IDeg Step wise

Group Type EXPERIMENTAL

insulin degludec

Intervention Type DRUG

Injected subcutaneously (under the skin) once daily. Dose individually adjusted in a stepwise manner.

Interventions

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insulin degludec

Injected subcutaneously (under the skin) once daily. Dose individually adjusted.

Intervention Type DRUG

insulin degludec

Injected subcutaneously (under the skin) once daily. Dose individually adjusted in a stepwise manner.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Type 2 diabetes (diagnosed clinically) for at least 24 weeks prior to randomisation (Visit 2)
* Current treatment: metformin monotherapy or metformin in any combination with 1 or 2 other OADs including an insulin secretagogue (sulfonylurea or glinide), dipeptidyl peptidase IV (DPP-IV) inhibitors, alpha-glucosidase inhibitors, thiazolidinediones (TZDs) all with unchanged dosing for at least 12 weeks prior to randomisation (Visit 2)-metformin: alone or in combination (including fixed combination) must be at least 1000 mg daily
* HbA1c 7.0-10.0% (both inclusive) by central laboratory analysis
* BMI (Body Mass Index) no higher than 45.0 kg/m\^2

Exclusion Criteria

* Treatment with glucagon-like peptide 1 (GLP-1) receptor agonist within the last 12 weeks prior to Visit 2
* Suffer from a life threatening disease (e.g. cancer)
* Females of childbearing potential who are pregnant (as determined by central laboratory beta-human chorionic gonadotropin (beta-hCG), breast feeding or intend to become pregnant or are not using adequate contraceptive methods (adequate contraceptive methods as required by law or practise \[for Germany, adequate contraceptive methods are: implants, injectables, combined oral contraceptives, hormonal IUD, sexual abstinence or vasectomised partner\])
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novo Nordisk A/S

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Global Clinical Registry (GCR, 1452)

Role: STUDY_DIRECTOR

Novo Nordisk A/S

Locations

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Novo Nordisk Investigational Site

Birmingham, Alabama, United States

Site Status

Novo Nordisk Investigational Site

Huntsville, Alabama, United States

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Novo Nordisk Investigational Site

Anaheim, California, United States

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Novo Nordisk Investigational Site

La Jolla, California, United States

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Novo Nordisk Investigational Site

Mission Hills, California, United States

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Novo Nordisk Investigational Site

National City, California, United States

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Novo Nordisk Investigational Site

North Hollywood, California, United States

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Novo Nordisk Investigational Site

San Diego, California, United States

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Novo Nordisk Investigational Site

Golden, Colorado, United States

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Novo Nordisk Investigational Site

Kissimmee, Florida, United States

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Novo Nordisk Investigational Site

Tampa, Florida, United States

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Novo Nordisk Investigational Site

Columbus, Georgia, United States

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Novo Nordisk Investigational Site

Springfield, Illinois, United States

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Novo Nordisk Investigational Site

Evansville, Indiana, United States

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Novo Nordisk Investigational Site

Slidell, Louisiana, United States

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Novo Nordisk Investigational Site

Billings, Montana, United States

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Novo Nordisk Investigational Site

Staten Island, New York, United States

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Novo Nordisk Investigational Site

Greensboro, North Carolina, United States

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Novo Nordisk Investigational Site

Franklin, Ohio, United States

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Novo Nordisk Investigational Site

Melrose Park, Pennsylvania, United States

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Novo Nordisk Investigational Site

East Providence, Rhode Island, United States

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Novo Nordisk Investigational Site

Humboldt, Tennessee, United States

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Novo Nordisk Investigational Site

Houston, Texas, United States

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Novo Nordisk Investigational Site

Killeen, Texas, United States

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Novo Nordisk Investigational Site

San Antonio, Texas, United States

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Novo Nordisk Investigational Site

Ogden, Utah, United States

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Novo Nordisk Investigational Site

St. George, Utah, United States

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Novo Nordisk Investigational Site

Helsinki, , Finland

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Novo Nordisk Investigational Site

Kerava, , Finland

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Novo Nordisk Investigational Site

Tampere, , Finland

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Novo Nordisk Investigational Site

Turku, , Finland

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Novo Nordisk Investigational Site

Turku, , Finland

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Novo Nordisk Investigational Site

Berlin, , Germany

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Novo Nordisk Investigational Site

Friedrichsthal, , Germany

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Novo Nordisk Investigational Site

Hohenmölsen, , Germany

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Novo Nordisk Investigational Site

Münster, , Germany

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Novo Nordisk Investigational Site

Neuwied, , Germany

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Novo Nordisk Investigational Site

Völklingen, , Germany

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Novo Nordisk Investigational Site

Almería, , Spain

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Novo Nordisk Investigational Site

Antequera, , Spain

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Novo Nordisk Investigational Site

Gijón, , Spain

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Novo Nordisk Investigational Site

Málaga, , Spain

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Novo Nordisk Investigational Site

Palma de Mallorca, , Spain

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Novo Nordisk Investigational Site

Palma de Mallorca, , Spain

Site Status

Novo Nordisk Investigational Site

Pozuelo de Alarcón, , Spain

Site Status

Countries

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United States Finland Germany Spain

References

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Philis-Tsimikas A, Brod M, Niemeyer M, Ocampo Francisco AM, Rothman J. Insulin degludec once-daily in type 2 diabetes: simple or step-wise titration (BEGIN: once simple use). Adv Ther. 2013 Jun;30(6):607-22. doi: 10.1007/s12325-013-0036-1. Epub 2013 Jun 29.

Reference Type RESULT
PMID: 23812875 (View on PubMed)

Related Links

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http://novonordisk-trials.com

Clinical Trials at Novo Nordisk

Other Identifiers

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U1111-1117-0616

Identifier Type: OTHER

Identifier Source: secondary_id

2010-022337-29

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

NN1250-3846

Identifier Type: -

Identifier Source: org_study_id

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