A Trial Assessing Changes in Blood Sugar and the Number of Periods Where Supplementation of Carbohydrate is Needed to Treat Low Blood Sugar, During Two Different Treatment Regimens of NN1250 in Type 1 Diabetics

NCT ID: NCT00964964

Last Updated: 2013-11-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-08-31

Study Completion Date

2009-09-30

Brief Summary

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This trial is conducted in Europe. The aim is to compare changes in blood sugar and the number of periods where carbohydrate supplementation is needed to treat low blood sugar, during two different treatments with NN1250 (insulin degludec), a soluble insulin basal analogue (SIBA) in subjects with type 1 diabetes.

Detailed Description

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Conditions

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Diabetes Diabetes Mellitus, Type 1

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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SIBA 3W

Group Type EXPERIMENTAL

insulin degludec

Intervention Type DRUG

Insulin degludec injected s.c. (under the skin) three times weekly

placebo

Intervention Type DRUG

Placebo injected s.c. (under the skin) four times weekly

SIBA OD

Group Type EXPERIMENTAL

insulin degludec

Intervention Type DRUG

Insulin degludec injected s.c. (under the skin) once daily for one week

Interventions

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insulin degludec

Insulin degludec injected s.c. (under the skin) three times weekly

Intervention Type DRUG

insulin degludec

Insulin degludec injected s.c. (under the skin) once daily for one week

Intervention Type DRUG

placebo

Placebo injected s.c. (under the skin) four times weekly

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Type 1 diabetes mellitus for at least 12 months
* Glycosylated haemoglobin (HbA1c) between 7.5 and 9% (both inclusive)

Exclusion Criteria

* Donation or loss of more than 500 ml blood or plasma within three months prior to this trial
* Smoker (defined as a subject who is smoking more than 5 cigarettes or the equivalent per day) or not able or willing to refrain from smoking and the use of nicotine gum or transdermal nicotine patches during the in-house periods
* Prior or current treatment with metformin or thiazolidinediones
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novo Nordisk A/S

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Global Clinical Registry (GCR, 1452)

Role: STUDY_DIRECTOR

Novo Nordisk A/S

Locations

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Neuss, , Germany

Site Status

Countries

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Germany

Related Links

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http://novonordisk-trials.com

Clinical Trials at Novo Nordisk

Other Identifiers

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2009-011959-53

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

NN1250-3765

Identifier Type: -

Identifier Source: org_study_id