Effect of Psychological Intervention on Drop-out Rates in IVF

NCT ID: NCT01318291

Last Updated: 2016-02-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

166 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-04-30

Study Completion Date

2014-09-30

Brief Summary

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The most common reason why insured In Vitro Fertilization (IVF) patients drop out of treatment is the distress caused by the treatment.

The objective of this study is to determine the efficacy of a combined Cognitive Coping and Relaxation Intervention (CCRI) in reducing drop out behavior in IVF patients.

Detailed Description

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Intervention participants will be given a packet containing the CCRI, which consists of two intervention components tailored to the Stimulation Phase and Waiting Phases of IVF. The cognitive component of the CCRI is the PRCI intervention (Boivin \& Lancastle, 2008) tailored to the stimulation/waiting phases of an IVF cycle. The PRCI intervention consists of a series of ten statements that facilitate the use of cognitive reappraisal coping, a form of coping that helps people think more about the positive aspects of a difficult situation and dwell less on problems or uncertainties of the future.

The relaxation components of the CCRI consists of techniques that have been used for two decades in the mind/body infertility program as well as in randomized controlled research trials. For the Stimulation phase, participants will receive instructions on how to do "mini relaxation" techniques which are specifically designed to reduce anxiety in the moment, for example feelings of tension, worry, and nervousness that might occur prior to and during Stimulation phase procedures (e.g. injections, blood tests, and ultrasounds). For the Waiting Phase the relaxation intervention will include a relaxation CD. The CD contains narrated instruction on how to elicit the relaxation response through several techniques

This is a randomized, controlled prospective study conducted at a private academically-affiliated infertility clinic and includes women ages 44 and below scheduled to undergo their first IVF cycle. Subjects are randomized to a CCRI or a control group. The primary outcome measure is dropout rates.

Conditions

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Infertility

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Caregivers

Study Groups

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Control

Group Type PLACEBO_COMPARATOR

Control

Intervention Type BEHAVIORAL

Medical treatment alone

CCRI Group

Group Type EXPERIMENTAL

CCRI Group

Intervention Type BEHAVIORAL

Cognitive Coping and Relaxation Intervention (CCRI) Cognitive Coping and Relaxation Intervention (CCRI) group who will receive a packet of relaxation and stress management suggestions

Interventions

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CCRI Group

Cognitive Coping and Relaxation Intervention (CCRI) Cognitive Coping and Relaxation Intervention (CCRI) group who will receive a packet of relaxation and stress management suggestions

Intervention Type BEHAVIORAL

Control

Medical treatment alone

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* First fresh IVF cycle
* Using own eggs
* Able to read, understand, and sign the informed consent in English
* Must have insurance coverage for IVF cycle

Exclusion Criteria

* \>1 previous IVF cycle
* Donor egg cycle
Minimum Eligible Age

18 Years

Maximum Eligible Age

44 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role collaborator

Boston IVF

OTHER

Sponsor Role lead

Responsible Party

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Alice D. Domar, PhD

Alice D. Domar, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Alice D Domar, PhD

Role: PRINCIPAL_INVESTIGATOR

Boston IVF

Jacky Boivin, PhD

Role: STUDY_DIRECTOR

School of Psychology, Cardiff University

Locations

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Boston IVF

Waltham, Massachusetts, United States

Site Status

Countries

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United States

References

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Domar AD, Gross J, Rooney K, Boivin J. Exploratory randomized trial on the effect of a brief psychological intervention on emotions, quality of life, discontinuation, and pregnancy rates in in vitro fertilization patients. Fertil Steril. 2015 Aug;104(2):440-51.e7. doi: 10.1016/j.fertnstert.2015.05.009. Epub 2015 Jun 13.

Reference Type DERIVED
PMID: 26072382 (View on PubMed)

Other Identifiers

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38844

Identifier Type: -

Identifier Source: org_study_id

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