Effects of Joint Effusion on Quadriceps Muscle

NCT ID: NCT01314820

Last Updated: 2011-03-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-06-30

Study Completion Date

2010-06-30

Brief Summary

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The present study investigated whether the presence of fluid in the joint affected peak torque and the root mean square (RMS) values of surface electromyography (EMG) in patients symptomatic for osteoarthritis (OA).

Detailed Description

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Several studies have shown that knee effusion influenced quadriceps muscle activity and induced quadriceps arthrogenic muscle inhibition in normal volunteers. However, the effect of joint effusion on the quadriceps of patients with OA is controversial,and few patients with OA have been included in studies of joint effusion.

Conditions

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Knee Osteoarthritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Investigators

Study Groups

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normal saline injection

20 cc normal saline injection into the knee joint

Group Type ACTIVE_COMPARATOR

normal saline injection

Intervention Type OTHER

20 cc normal saline injection into knee joint

sham injection

knee injection without saline

Group Type SHAM_COMPARATOR

sham injection

Intervention Type OTHER

no saline injection

Interventions

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normal saline injection

20 cc normal saline injection into knee joint

Intervention Type OTHER

sham injection

no saline injection

Intervention Type OTHER

Other Intervention Names

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normal saline no normal saline

Eligibility Criteria

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Inclusion Criteria

* 50 years old or older with knee osteoarthritis
* knee pain without joint effusion confirmed by ultrasonography

Exclusion Criteria

* the presence of knee joint effusion determined using US
* a history of knee injury or surgery
* a history of knee injection within 3 months
* a history of inflammatory arthritis
* taking anticoagulants
* balance or gait disturbance
* diabetes mellitus
Minimum Eligible Age

50 Years

Maximum Eligible Age

75 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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The Catholic University of Korea

OTHER

Sponsor Role lead

Responsible Party

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College of Medicine, The Catholic University of Korea

Principal Investigators

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Jongin Lee, M.D

Role: STUDY_DIRECTOR

Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea

Locations

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Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea

Seoul, Seoul, South Korea

Site Status

Countries

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South Korea

References

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Fahrer H, Rentsch HU, Gerber NJ, Beyeler C, Hess CW, Grunig B. Knee effusion and reflex inhibition of the quadriceps. A bar to effective retraining. J Bone Joint Surg Br. 1988 Aug;70(4):635-8. doi: 10.1302/0301-620X.70B4.3403614.

Reference Type BACKGROUND
PMID: 3403614 (View on PubMed)

Jones DW, Jones DA, Newham DJ. Chronic knee effusion and aspiration: the effect on quadriceps inhibition. Br J Rheumatol. 1987 Oct;26(5):370-4. doi: 10.1093/rheumatology/26.5.370.

Reference Type BACKGROUND
PMID: 3664162 (View on PubMed)

Rice D, McNair PJ, Dalbeth N. Effects of cryotherapy on arthrogenic muscle inhibition using an experimental model of knee swelling. Arthritis Rheum. 2009 Jan 15;61(1):78-83. doi: 10.1002/art.24168.

Reference Type BACKGROUND
PMID: 19116960 (View on PubMed)

Other Identifiers

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KC09OISI0161

Identifier Type: -

Identifier Source: org_study_id

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