Chemokine Expression in Nummular Dermatitis and Atopic Dermatitis
NCT ID: NCT01311986
Last Updated: 2011-04-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
120 participants
OBSERVATIONAL
2010-11-30
2012-03-31
Brief Summary
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Detailed Description
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Nummular dermatitis(ND) is another common cutaneous inflammatory disease. The nummular patches and papules disseminated over four extremities and less over trunk . The serum levels of Th2 chemokines(CCL17, CCL22, CCL27) are elevated in AD patients. The expression levels of these chemokines in lesional epidermis are also increased. CCL18 which is derived from APC is also increased in the serum as well as lesional skin of AD patients. In contrast, there are very few reports regarding the chemokine expression profiles in ND patients. Because erosis is a remarkable exacerbating factor for ND. The investigators hypothesize that ND is a specialized contact dermatitis induced by environmental substances. It has been known, CCL17 and CXCL10 were highly expressed in lesion of allergic contant dermatitis, whereas almost no expression of these chemokines could be detected in lesions of irritant contact dermatitis.
The aim of this study is to measure the serum levels of CCL17, CCL18, CCL22 and CXCL10 and their expression levels in epidermis in AD and ND patients. The investigators hope that the results of this study will provide useful information for clinical differential diagnosis for AD and ND as well as understanding the pathogenesis of ND.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Patients with atopic dermatitis
No interventions assigned to this group
Patients with nummular eczema
No interventions assigned to this group
Normal control
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* age:20\~40, nummular patches\>10, no atopy
Exclusion Criteria
* high dose topical immunosuppresive agents within 4 weeks
20 Years
40 Years
ALL
Yes
Sponsors
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National Taiwan University Hospital
OTHER
Responsible Party
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Department of Dermatology, National Taiwan University Hospital
Principal Investigators
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Hsien-Ching Chiu, MD
Role: PRINCIPAL_INVESTIGATOR
Department of Dermatology, National Taiwan University Hospital
Locations
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National Taiwan University Hospital
Taipei, Taipei, Taiwan
Countries
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Other Identifiers
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201006030R
Identifier Type: -
Identifier Source: org_study_id
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