Lower Urinary Tract Dysfunction Database

NCT ID: NCT01293110

Last Updated: 2025-04-03

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 7000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-01-31
• Study Completion Date: 2030-01-31

Brief Summary

Patients with neurological disease/injury often suffer from lower urinary tract symptoms, which frequently have a negative impact on the patients' health related quality of life. The prevalence of lower urinary tract dysfunction is high and the treatment is a challenge because available treatments may fail. In this study data of patients with lower urinary tract dysfunction treated at the University of Zürich, are prospectively and systematically collected in a database.

Detailed Description

Lower urinary tract dysfunction is characterized by detrusor overactivity, detrusor sphincter dyssynergia, voiding dysfunction, stress incontinence, or a combination of these and frequently has a negative impact on the patients' health related quality of life. In addition, the treatment of lower urinary tract dysfunction is a challenge because conventional therapies may fail. Adequate treatment and long-term follow-up of lower urinary tract dysfunction is important to achieve/maintain continence and preserve renal function. Thus, we aim to prospectively collect clinical, video-urodynamic and radiological data of patients with neurogenic lower urinary tract dysfunction treated at the University of Zürich in a database.

Conditions

Neurogenic Bladder; Diseases of the Lower Urinary Tract: General Conditions

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• patient of Balgrist University Hospital
• patient of University Hospital Zürich
• urodynamic examination
• written informed consent

Exclusion Criteria

• no written informed consent

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Zurich

OTHER

Sponsor Role: lead

Responsible Party

Thomas Kessler

executive physician

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Thomas M Kessler

Role: PRINCIPAL_INVESTIGATOR

Universitätsklinik Balgrist

Locations

Spinal Cord Injury Center & Research, University of Zürich, Balgrist University Hospital

Zurich, Canton of Zurich, Switzerland

Site Status: RECRUITING

Countries

Switzerland

Central Contacts

Thomas M Kessler, MD

Role: CONTACT

thomas.kessler@balgrist.ch

+41 44 386 39 07

Facility Contacts

Thomas M Kessler, MD

Role: primary

thomas.kessler@balgrist.ch

+41 44 386 39 07

References

Walter M, Knupfer SC, Cragg JJ, Leitner L, Schneider MP, Mehnert U, Krassioukov AV, Schubert M, Curt A, Kessler TM. Prediction of autonomic dysreflexia during urodynamics: a prospective cohort study. BMC Med. 2018 Apr 13;16(1):53. doi: 10.1186/s12916-018-1040-8.

Reference Type: DERIVED

PMID: 29650001 (View on PubMed)

Leitner L, Guggenbuhl-Roy S, Knupfer SC, Walter M, Schneider MP, Tornic J, Sammer U, Mehnert U, Kessler TM. More Than 15 Years of Experience with Intradetrusor OnabotulinumtoxinA Injections for Treating Refractory Neurogenic Detrusor Overactivity: Lessons to Be Learned. Eur Urol. 2016 Sep;70(3):522-8. doi: 10.1016/j.eururo.2016.03.052. Epub 2016 Apr 19.

Reference Type: DERIVED

PMID: 27106070 (View on PubMed)

Other Identifiers

KEK-2010-0207/0/PB_2016-0189

Identifier Type: -

Identifier Source: org_study_id