Observational Study of Blood Pressure Measurements and Continuous Dialysis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

7 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-02-28

Study Completion Date

2015-12-31

Brief Summary

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Dialysis is used to control the fluid balance and metabolic state of patients with kidney disease. Control of the metabolic state, via electrolytes, can be monitored using labs that are routinely drawn from patients undergoing continuous hemodialysis. Control of fluid removal is much more difficult. This study aims to determine whether changes in the blood pressure associated with breathing correlate with or predict intolerance to fluid responsiveness with continuous dialysis.

We hypothesize that a measurement of changes in blood pressure with breathing called arterial pulse pressure variation may be able to predict the ability to remove fluid during continuous renal replacement therapy.

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Detailed Description

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Conditions

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Kidney Failure Respiratory Failure Critical Illness Shock

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Mechanically ventilated patients

No interventions assigned to this group

Non-mechanically ventilated patients

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* age \> 17 years old
* CVVHD renal replacement therapy
* indwelling arterial line

Exclusion Criteria

* age \< 18 years old
* pregnancy
* temperature \< 34°C
* severe mechanical ventilator dyssynchrony
* cardiac arrhythmias precluding automated PPV measurement by ICU monitors
* non-pulsatile cardiac flow
* open thoracic cavity

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No