Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-11-30

Study Completion Date

2011-12-31

Brief Summary

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The purpose of this study is to assess the comparative efficacy of retinol 1.0% and tretinoin 0.02% in minimizing wrinkles, discoloration, roughness, and other signs of moderate to severe photodamage. Our hypothesis is that both products will be of comparable benefit.

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Detailed Description

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Conditions

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Photodamaged Skin Wrinkles

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Retinol

Retinol 1.0% cream

Group Type ACTIVE_COMPARATOR

Retinol

Intervention Type DRUG

1.0% cream

Tretinoin

Tretinoin 0.02% cream

Group Type ACTIVE_COMPARATOR

Tretinoin

Intervention Type DRUG

0.02% cream

Interventions

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Retinol

1.0% cream

Intervention Type DRUG

Tretinoin

0.02% cream

Intervention Type DRUG

Other Intervention Names

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Retin-A Renova Atralin Aberela Airol Avita Stieva-A

Eligibility Criteria

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Inclusion Criteria

* Age 35 or over
* Moderate to severe photodamage

Exclusion Criteria

* History of facial cosmetic surgery, facial resurfacing procedures, deep peels, or facial fillers
* History of keloids or hypertrophic scars
* Use of oral steroids or oral retinoids (such as Accutane) in past 6 months

Minimum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No