Comparison of Single Versus Repeat Doses of AM-101 in the Treatment of Acute Inner Ear Tinnitus

NCT ID: NCT01270282

Last Updated: 2015-01-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

82 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-02-28

Study Completion Date

2013-05-31

Brief Summary

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The purpose of the study is to evaluate the therapeutic benefit and safety of intratympanic AM-101 injections in comparison to placebo in the treatment of persistent acute inner ear tinnitus.

Detailed Description

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Conditions

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Tinnitus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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AM-101 0.81 mg/mL

Gel for injection; single or triple injection

Group Type EXPERIMENTAL

AM-101 0.81 mg/mL

Intervention Type DRUG

Placebo

Gel for injection; single or triple injection

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Interventions

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AM-101 0.81 mg/mL

Intervention Type DRUG

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Tinnitus following acute acoustic trauma, acute otitis media, middle ear surgery or inner ear barotrauma; with onset less than three months ago.

Exclusion Criteria

* Tinnitus that is not completely maskable
* Fluctuating tinnitus
* Intermittent tinnitus
* Meniere's Disease
* Ongoing acute or chronic otitis media or otitis externa.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Auris Medical, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Florida College of Medicine

Gainsville, Florida, United States

Site Status

University of Kansas Medical Center

Kansas City, Kansas, United States

Site Status

Advanced ENT & Allergy

Louisville, Kentucky, United States

Site Status

Summit Medical Group

Berkeley Heights, New Jersey, United States

Site Status

PMG Research of Winston-Salem

Winston-Salem, North Carolina, United States

Site Status

UZ Antwerp, Department of ENT

Edegem, , Belgium

Site Status

Gent University Hospital, Department of ENT

Ghent, , Belgium

Site Status

Virga Jesseziekenhuis Hasselt

Hasselt, , Belgium

Site Status

HNO Praxis im Schlosscarree

Braunschweig, , Germany

Site Status

HNO Praxis

Cologne, , Germany

Site Status

Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie

Frankfurt am Main, , Germany

Site Status

HNO Gemeinschaftspraxis

Heidelberg, , Germany

Site Status

Bundeswehrkrankenhaus Ulm

Ulm, , Germany

Site Status

NZOZ Laryngologii Wojewodzki Szpital Specjalistyczny

Rzeszów, , Poland

Site Status

NZOZ Centrum Medyczne LiMED

Tarnowskie Góry, , Poland

Site Status

Samodzielny Publiczny Centralny Szpital Kliniczny w Warszawie

Warsaw, , Poland

Site Status

Countries

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United States Belgium Germany Poland

Other Identifiers

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AM-101-CL-10-02

Identifier Type: OTHER

Identifier Source: secondary_id

AM-101-CL-10-02

Identifier Type: -

Identifier Source: org_study_id

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