Penicillin and Metronidazole in Treatment of Peritonsillar Abscess
NCT ID: NCT01255670
Last Updated: 2021-05-11
Study Results
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View full resultsBasic Information
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COMPLETED
NA
200 participants
INTERVENTIONAL
2010-02-28
2011-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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penicillin and metronidazole
After incision and drainage 100 randomized patients receive penicillin and metronidazole as treatment of peritonsillar abscess
penicillin and metronidazole in peritonsillar abscess
Peroral Penicillin: 1000 000 IU 3 times a day for 10 days Peroral metronidazole: 500 mg 3 times a day for 7 days
penicillin and placebo
After incision and drainage 100 randomized patients receive penicillin and placebo as treatment of peritonsillar abscess
penicillin and metronidazole in peritonsillar abscess
Peroral Penicillin: 1000 000 IU 3 times a day for 10 days Peroral metronidazole: 500 mg 3 times a day for 7 days
Interventions
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penicillin and metronidazole in peritonsillar abscess
Peroral Penicillin: 1000 000 IU 3 times a day for 10 days Peroral metronidazole: 500 mg 3 times a day for 7 days
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* patient is voluntary
* patient has daily access to his/her e-mail
* patient speaks and understands Finnish of Swedish
* female patients have adequate birth-control method
* patient has peritonsillar abscess
Exclusion Criteria
* allergy to metronidazole
* use of metronidazole in preceding one month
* pregnancy
* breast-feeding
* renal insufficiency
* liver insufficiency
* alcoholism (drunk at least once a week)
* participant in another clinical trial at the moment
* treatment of peritonsillar abscess requires in-patient care
* tonsillectomy during the next 30 days
* army recruit
18 Years
ALL
No
Sponsors
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Helsinki University Central Hospital
OTHER
Responsible Party
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Karin Blomgren
Senior Medical Officer in Charge of Research
Principal Investigators
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Karin V Blomgren, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
consultant
Locations
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Helsinki University Central Hospital
Helsinki, , Finland
Countries
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References
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Wiksten JE, Pitkaranta A, Blomgren K. Metronidazole in conjunction with penicillin neither prevents recurrence nor enhances recovery from peritonsillar abscess when compared with penicillin alone: a prospective, double-blind, randomized, placebo-controlled trial. J Antimicrob Chemother. 2016 Jun;71(6):1681-7. doi: 10.1093/jac/dkw038. Epub 2016 Mar 10.
Other Identifiers
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224/13/03/02/2009
Identifier Type: -
Identifier Source: org_study_id
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