"Volatile Anesthetic Protection Of Renal Transplants: VAPOR-1-trail

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-09-30

Study Completion Date

2012-10-31

Brief Summary

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To compare the renal protective properties of two currently used anaesthetic techniques - a sevoflurane-remifentanil/sufentanil combination with a propofol-remifentanil/sufentanil combination for anaesthesia in patients undergoing living donor kidney donation/transplantation.

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Detailed Description

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Conditions

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Kidney Donation/Transplantation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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SEVO

sevoflurane-remifentanil/sufentanil combination

Group Type ACTIVE_COMPARATOR

procedure:sevoflurane-remifentanil/sufentanil

Intervention Type DRUG

Active Comparator

SERE

volatile agent only during reperfusion

Group Type ACTIVE_COMPARATOR

volatile agent only during reperfusion

Intervention Type DRUG

Active Comparator

propofol

propofol-remifentanil/sufentanil

Group Type ACTIVE_COMPARATOR

propofol-remifentanil/sufentanil

Intervention Type DRUG

Active Comparator

Interventions

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procedure:sevoflurane-remifentanil/sufentanil

Active Comparator

Intervention Type DRUG

volatile agent only during reperfusion

Active Comparator

Intervention Type DRUG

propofol-remifentanil/sufentanil

Active Comparator

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* All patients: Age \> 18 years

Exclusion Criteria

* patient refusal
* BMI\< 17, \>35
* neurological disorder
* recent use of psycho-active medication, including alcohol.
* Donor-recipient couples from the ABO-incompatible program
* Altruistic donor

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No