The Expression of TLR2 and TLR4 in the Lung of Chronic Obstructive Pulmonary Disease (COPD) Patients

NCT ID: NCT01226199

Last Updated: 2011-06-08

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 60 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-10-31
• Study Completion Date: 2012-03-31

Brief Summary

Smoking is the most important risk factor of COPD, but only a fourth of smokers had COPD in their life. There are also healthy smokers without evidence of COPD. Investigators hypothesize that innate immunity may affect this difference between COPD patients and healthy smokers, because TLR4 is the receptor of LPS, which is the one of important substance in cigarette. Investigators will measure TLR2 and TLR4 expression in lung tissue of patients whose lung will be resected. Investigators will compare the level of expression between COPD patients and healthy smokers.

Conditions

Smoking; COPD

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• All patients who will have lung resection for the therapeutic cause.

Exclusion Criteria

• Patients who do not agree with our study protocol

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Seoul National University Bundang Hospital

OTHER

Sponsor Role: lead

Responsible Party

Seoul National University Bundang Hospital

Locations

Seoul National University Bundang Hospital

Seongnam, Gyeongi, South Korea

Site Status: RECRUITING

Countries

South Korea

Central Contacts

Sei Won Lee, MD

Role: CONTACT

seiwon@snubh.org

82 31 787 7053

Facility Contacts

Sei Won Lee, MD

Role: primary

seiwon@snubh.org

82 31 787 7053

Other Identifiers

TLR2 and TLR4 in COPD tissue

Identifier Type: -

Identifier Source: org_study_id