Bendamustine and Dexamethasone in Patients With Relapsed AL Amyloidosis

NCT ID: NCT01222260

Last Updated: 2020-03-30

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-01-31
• Study Completion Date: 2019-07-03

Brief Summary

The study is being done to see if the combination of bendamustine and dexamethasone will help people with amyloidosis that has returned after standard treatment, and to to estimate the partial hematologic response rate (PHR).

Detailed Description

Systemic light-chain amyloidosis (AL) is a protein conformation disorder due to a clonal plasma cell dyscrasia. There are no established and approved second-line therapies for patients with systemic AL amyloidosis who fail initial melphalan-based treatment, be it high-dose melphalan with stem cell transplant or oral melphalan and dexamethasone (MDex). Therefore new treatments are needed for those who fail initial therapy and for those who initially respond but subsequently relapse.

Therapy of AL is generally based on treatment regimens used in multiple myeloma (MM). Bendamustine achieves partial response with relapsed/refractory MM. Based on this high anti-MM activity, we anticipate that bendamustine will also be very active in clonal plasma cell disorder associated with AL.

Conditions

AL Amyloidosis

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Treatment Arm

Subjects with AL will receive Bendamustine and Dexamethasone

Group Type: EXPERIMENTAL

Bendamustine

Intervention Type: DRUG

Patients will start bendamustine at dose level 0 and according to CrCl on day 1 and 2 of each cycle:

• CrCl ≥ 60 mL/min: 100 mg/m2 IV on day 1 and 2 of each cycle
• CrCl 59 - 30 mL/min: 90 mg/m2 IV on day 1 and 2 of each cycle

Available to qualifying subjects is the option to dose escalate to dose level (+)1:

• 120 mg/m2 (if CrCl ≥ 60 mL/min at the time of inclusion into the study)
• 100 mg/m2 (if CrCl 59-30 mL/min at the time of inclusion into the study)

Dexamethasone

Intervention Type: DRUG

40 mg orally on days 1, 8, 15, 22 of each cycle

Interventions

Bendamustine

Patients will start bendamustine at dose level 0 and according to CrCl on day 1 and 2 of each cycle:

• CrCl ≥ 60 mL/min: 100 mg/m2 IV on day 1 and 2 of each cycle
• CrCl 59 - 30 mL/min: 90 mg/m2 IV on day 1 and 2 of each cycle

Available to qualifying subjects is the option to dose escalate to dose level (+)1:

• 120 mg/m2 (if CrCl ≥ 60 mL/min at the time of inclusion into the study)
• 100 mg/m2 (if CrCl 59-30 mL/min at the time of inclusion into the study)

Intervention Type: DRUG

Dexamethasone

40 mg orally on days 1, 8, 15, 22 of each cycle

Intervention Type: DRUG

Other Intervention Names

Bendamustine Hydrochloride; Treanda ®; Decadron

Eligibility Criteria

Inclusion Criteria

• Male or female patients aged ≥ 18 years old
• Histopathology of amyloidosis or light chain deposition disease based on detection by polarizing microscopy of green bi-refringent material in Congo red-stained tissue specimens or characteristic electron microscopy appearance or immunohistochemical stain with anti-light chain anti-sera
• Demonstrate measurable disease as defined by one or more of the following:

• Serum monoclonal protein ≥ 0.5 g/dL by serum electrophoresis
• Urine monoclonal protein > 200 mg/dL in a 24 hr urine electrophoresis
• Serum immunoglobulin free light chain ≥ 5 mg/dL and abnormal serum immunoglobulin kappa lambda free light chain ratio. The difference between involved and uninvolved free light chains should be ≥ 5 mg/dL (dFLC)
• Demonstrate clonal population of plasma cells in the bone marrow or immunohistochemical stain with anti-light chain anti-sera of amyloid fibrils
• Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2
• Patients had at least one prior regimen consisting of at least 1 cycle
• If not previously transplanted, patient should be either ineligible for autologous stem cell transplantation (ASCT), or must have declined the option of ASCT. Patients who have previously had ASCT and have subsequently progressed are eligible, provided other entry criteria are met
• Ability to provide written informed consent obtained prior to participation in the study and any related procedures being performed

Patients must meet the following laboratory criteria:

• Absolute neutrophil count (ANC) ≥ 1.5 x 10^9/L
• Hemoglobin ≥ 9 g/dl (May transfuse packed red blood cells (PRBC) to meet parameter)
• Platelets ≥ 100x 10^9/L (Must be independent of platelet transfusion)
• Calculated creatinine clearance (CrCl) greater than or equal to 30 mL/min (Cockcroft-Gault Formula )
• Aspartate transaminase (AST) and alanine transaminase (ALT) ≤ 2.5 x upper limit of normal (ULN)
• Serum bilirubin <1.5 x ULN
• Serum potassium within normal limits
• Total serum calcium (corrected for serum albumin) or ionized calcium ≤ ULN

Exclusion Criteria

• Patients meeting the criteria for symptomatic MM:
• Lytic lesions on skeletal survey or plasmacytoma

Patients meeting International Myeloma Working Group definition of symptomatic myeloma with symptoms only related to associated amyloidosis who would otherwise only meet the criteria for smoldering MM are potentially eligible

• Myocardial infarction within 6 months prior to enrollment or has New York Heart Association (NYHA) Class III or IV heart failure uncontrolled angina, severe uncontrolled ventricular arrhythmias, or
• electrocardiographic evidence of acute ischemia or active conduction system abnormalities (not including 1st degree atrioventricular (AV)-block, Wenckebach type 2nd degree heart block, or left bundle branch block. Prior to study entry, any electrocardiogram (ECG) abnormality at Screening has to be documented by the investigator or an authorized physician sub-investigator as not medically relevant). Note: There is no lower limit of left ventricular ejection fraction below which patients are excluded from participation.
• Patients with N-terminal (NT)-proBNP ≥ 1800nb/L or B-type natriuretic peptide (BNP) ≥ 400 ng/L, abnormal cardiac troponin T (cTnT) or cardiac troponin l (cTnI)
• Patient has received other investigational drugs within 14 days prior to enrollment
• Any form of secondary / familial amyloidosis
• Serious concurrent illness, which in the opinion of the investigator or an authorized physician sub-investigator would interfere with participation in this clinical study,
• Known HIV infection.
• Inability to provide informed consent or to comply with the schedule of office and treatment visits
• Female subject is pregnant or breast-feeding. Confirmation that the subject is not pregnant must be established by a negative serum beta-human chorionic gonadotropin pregnancy test result obtained during screening. Pregnancy testing is not required for post-menopausal or surgically sterilized women(woman not of child-bearing potential is defined as any woman whose menstrual periods have stopped in the past 12 consecutive months or have had a complete hysterectomy or both ovaries surgically removed).
• Diagnosed or treated for another malignancy within 3 years of enrollment, with the exception of complete resection of basal cell carcinoma or squamous cell carcinoma of the skin, an in situ malignancy, low-risk prostate cancer, or cancer after curative treatment.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cephalon

INDUSTRY

Sponsor Role: collaborator

Columbia University

OTHER

Sponsor Role: lead

Responsible Party

Suzanne Lentzsch, MD

Associate Professor of Clinical Medicine

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Suzanne Lentzsch, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Columbia University

Locations

Tufts Medical Center

Boston, Massachusetts, United States

Boston Medical Center

Boston, Massachusetts, United States

Barbara Ann Karmanos Cancer Institute

Detroit, Michigan, United States

Mt. Sinai Medical Center

New York, New York, United States

Columbia University

New York, New York, United States

Memorial Sloan-Kettering Cancer Center

New York, New York, United States

Countries

United States

References

Lentzsch S, Lagos GG, Comenzo RL, Zonder JA, Osman K, Pan S, Bhutani D, Pregja S, Sanchorawala V, Landau H. Bendamustine With Dexamethasone in Relapsed/Refractory Systemic Light-Chain Amyloidosis: Results of a Phase II Study. J Clin Oncol. 2020 May 1;38(13):1455-1462. doi: 10.1200/JCO.19.01721. Epub 2020 Feb 21.

Reference Type: DERIVED

PMID: 32083996 (View on PubMed)

Provided Documents

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

10-012 (PRO10050217)

Identifier Type: OTHER

Identifier Source: secondary_id

AAAJ7800

Identifier Type: -

Identifier Source: org_study_id