Mentalization - Based Treatment: Adolescents With Co-morbid Depression and Personality Disorder

NCT ID: NCT01204346

Last Updated: 2014-10-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

75 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-12-31

Study Completion Date

2016-12-31

Brief Summary

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Mentalisation based treatment (MBT) for young people with co-morbid depression and emerging personality disorder will be more effective in a day/inpatient setting than treatment as usual.

Detailed Description

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Systematic literature review on outcomes with young people with depression and emerging personality disorder showed clear evidence that this group of young people are severely hampered and adult outcomes are strongly linked to both adult PD as well as adult psychiatric disturbance and lower levels of adult functioning. (Crawford et al, 2008; Kasen et al, 1999; Kasen et al, 2007; Lewinsohn et al, 1999) This argues very clearly for the need to diagnose young people presenting with co-morbid depression and emerging personality disorder in order to intervene and help these young people's struggles as it will prevent poor prognostic adult outcomes. There were no treatment programs that specifically focussed on the treatment of this co-morbid group in the literature. Several studies focussed on the treatment of depression alone and only one RCT focussed on the treatment of adolescent personality disorder (Chanen et al, 2007). In adult studies mentalization-based treatment programs were found to be effective ( as well as cost effective) in a day hospital setting for adults with personality disorder and depression (Bateman, et al, 2007) This study aims to conduct a control trial to test whether MBT will be more effective than TAU in this group. All cases will be tested on admission, at discharge and followed up at 2 years post discharge.

Conditions

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Depression Personality Disorder

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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MBT group

mentalization based treatment program

Group Type EXPERIMENTAL

MBT

Intervention Type OTHER

The intervention consists of twice weekly individual MBT therapy, group therapy with an MBT focus and weekly MBFT, which is MBT for families. The treatment duration will be 6-8 weeks.

Treatment as usual group

treatment as usual group

Group Type ACTIVE_COMPARATOR

treatment as usual

Intervention Type OTHER

less intensive and structured psychotherapeutic program

Interventions

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MBT

The intervention consists of twice weekly individual MBT therapy, group therapy with an MBT focus and weekly MBFT, which is MBT for families. The treatment duration will be 6-8 weeks.

Intervention Type OTHER

treatment as usual

less intensive and structured psychotherapeutic program

Intervention Type OTHER

Other Intervention Names

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Psychotherapeutic program Psychotherapeutic program

Eligibility Criteria

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Inclusion Criteria

* all young people who are admitted to Brookside adolescent unit between the ages 12 - 17 presenting with depression and emerging personality disorder will be eligible

Exclusion Criteria

* Young people with autistic spectrum disorders or severe learning disabilities.
Minimum Eligible Age

12 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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North East London Foundation Trust

OTHER

Sponsor Role lead

Responsible Party

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Trudie Rossouw

Dr

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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trudie i rossouw, dr

Role: PRINCIPAL_INVESTIGATOR

North East London Foundation Trust

Locations

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North East London Foundation Trust

Ilford, Essex, United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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trudie I Rossouw, Dr

Role: CONTACT

+448446001200

Facility Contacts

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trudie i rossouw, dr

Role: primary

+448446001200

References

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Bateman A, Fonagy P. Mentalization based treatment for borderline personality disorder. World Psychiatry. 2010 Feb;9(1):11-5. doi: 10.1002/j.2051-5545.2010.tb00255.x.

Reference Type BACKGROUND
PMID: 20148147 (View on PubMed)

Bateman A, Fonagy P. Randomized controlled trial of outpatient mentalization-based treatment versus structured clinical management for borderline personality disorder. Am J Psychiatry. 2009 Dec;166(12):1355-64. doi: 10.1176/appi.ajp.2009.09040539. Epub 2009 Oct 15.

Reference Type BACKGROUND
PMID: 19833787 (View on PubMed)

Crawford TN, Cohen P, First MB, Skodol AE, Johnson JG, Kasen S. Comorbid Axis I and Axis II disorders in early adolescence: outcomes 20 years later. Arch Gen Psychiatry. 2008 Jun;65(6):641-8. doi: 10.1001/archpsyc.65.6.641.

Reference Type BACKGROUND
PMID: 18519822 (View on PubMed)

Kasen S, Cohen P, Skodol AE, Johnson JG, Brook JS. Influence of child and adolescent psychiatric disorders on young adult personality disorder. Am J Psychiatry. 1999 Oct;156(10):1529-35. doi: 10.1176/ajp.156.10.1529.

Reference Type BACKGROUND
PMID: 10518162 (View on PubMed)

Kasen S, Cohen P, Skodol AE, First MB, Johnson JG, Brook JS, Oldham JM. Comorbid personality disorder and treatment use in a community sample of youths: a 20-year follow-up. Acta Psychiatr Scand. 2007 Jan;115(1):56-65. doi: 10.1111/j.1600-0447.2006.00842.x.

Reference Type BACKGROUND
PMID: 17201867 (View on PubMed)

Lewinsohn PM, Rohde P, Klein DN, Seeley JR. Natural course of adolescent major depressive disorder: I. Continuity into young adulthood. J Am Acad Child Adolesc Psychiatry. 1999 Jan;38(1):56-63. doi: 10.1097/00004583-199901000-00020.

Reference Type BACKGROUND
PMID: 9893417 (View on PubMed)

Chanen AM, McCutcheon LK, Jovev M, Jackson HJ, McGorry PD. Prevention and early intervention for borderline personality disorder. Med J Aust. 2007 Oct 1;187(S7):S18-21. doi: 10.5694/j.1326-5377.2007.tb01330.x.

Reference Type BACKGROUND
PMID: 17908019 (View on PubMed)

Related Links

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http://www.nelft.nhs.uk/

host NHS organisation

Other Identifiers

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TRossouw

Identifier Type: -

Identifier Source: org_study_id

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