Dose Escalation of IPI-493 in Hematologic Malignancies

NCT ID: NCT01193491

Last Updated: 2015-04-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE1

Total Enrollment

4 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-06-30

Study Completion Date

2011-07-31

Brief Summary

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The purpose of this study is to evaluate the safety, determine the maximum tolerated dose (MTD) and schedule of IPI-493 in patients with hematologic malignancies.

Detailed Description

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Conditions

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Hematologic Malignancies

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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IPI-493

Group Type EXPERIMENTAL

IPI-493

Intervention Type DRUG

Capsules, ascending dose, multiple schedules

Interventions

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IPI-493

Capsules, ascending dose, multiple schedules

Intervention Type DRUG

Other Intervention Names

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HSP-90 Geldanamycin

Eligibility Criteria

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Inclusion Criteria

* \>/=18 years old
* ECOG 0-1
* confirmed hematological malignancy
* refractory to available therapy or for which no therapy is available
* adequate hepatic, renal function

Exclusion Criteria

* active CNS malignancy
* prolonged QT interval
* significant GI/liver disease
* other serious concurrent illness or medical condition
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Infinity Pharmaceuticals, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Robert Ross, M.D.

Role: STUDY_DIRECTOR

Infinity Pharmaceuticals, Inc.

Locations

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Johns Hopkins Sidney Kimmel Cancer Center

Baltimore, Maryland, United States

Site Status

Weill Cornell Cancer Center

New York, New York, United States

Site Status

M.D. Anderson Cancer Center

Houston, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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IPI-493-02

Identifier Type: -

Identifier Source: org_study_id

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