Eosinophil Markers and Development of Disease in Allergic Rhinitis

NCT ID: NCT01192386

Last Updated: 2010-09-01

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 29 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-05-31
• Study Completion Date: 2010-05-31

Brief Summary

Inflammatory proteins from eosinophil granulocytes in blood from patients with seasonal allergic hayfever have been shown to predict development of asthma at a six-year follow-up. This study is a 15-year follow-up of the same patients to verify earlier results and study disease development.

Detailed Description

The study consists of a single visit at which patients fill in a questionnaire on actual hayfever and asthma symptoms as well as current treatment. Blood samples and nasal lavages are drawn and analysed for eosinophils as well as eosinophil cationic protein and tryptase. Spirometry is performed.

If patients use drugs which can interfere with results, ie. corticosteroids or beta-agonists, biochemistry and/or spirometry are omitted.

Conditions

Seasonal Allergic Rhinitis

Eligibility Criteria

Inclusion Criteria

• Participant in earlier study (1995)

Exclusion Criteria

• Treatment with any kind of corticosteroid within two months will exclude from study of inflammatory parameters

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Aarhus University Hospital

OTHER

Sponsor Role: collaborator

University of Aarhus

OTHER

Sponsor Role: lead

Responsible Party

Department of Respiratory Research, Aarhus University Hospital

Principal Investigators

Lars Peter Nielsen, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Respiratory Research, Aarhus University Hospital, DK-8000 Aarhus C, Denmark

Other Identifiers

RHINO2010

Identifier Type: -

Identifier Source: org_study_id