Treatment for Young Adults With Anorexia Nervosa

NCT ID: NCT01190423

Last Updated: 2018-04-17

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 22 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-07-31
• Study Completion Date: 2016-04-30

Brief Summary

Temple University is conducting a National Institute of Health funded research study designed to develop and refine a family-based treatment manual for young adults with Anorexia Nervosa as well as assess the feasibility of this out-patient psychotherapy.

Detailed Description

Anorexia Nervosa (AN) is a serious psychiatric illness that occurs in an estimated 0.5 to 3.7% of women. The illness severely affects physical, emotional, and social functioning. The mortality rates associated with this severely disabling condition are higher than those for any other psychiatric disorder and substantially higher than those expected in the general population. Lower weight at presentation, longer illness duration, and alcohol abuse are associated with a higher risk of mortality.

Treatment-outcome for adult AN is poor with a quarter of adults with AN having poor outcome. In AN, promising outcomes are seen in family-based treatment (FBT) for adolescent patients who present between the ages of 12 to 18 with a short duration of illness. A manualized version of FBT has now been tested in several studies and case series, showing that well over 80% of participants had good or intermediate outcome at post-treatment. Despite its efficacy with adolescents, FBT has not been utilized with young adults.

The purpose of this study is to develop and refine FBT to promote weight gain in young adults with Anorexia Nervosa.

Conditions

Anorexia Nervosa

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Family Based therapy for young adults

Group Type: EXPERIMENTAL

Family Based Therapy for young adults

Intervention Type: BEHAVIORAL

Individual and Group Therapy Sessions

Interventions

Family Based Therapy for young adults

Individual and Group Therapy Sessions

Intervention Type: BEHAVIORAL

Other Intervention Names

FBT; FBT-Y

Eligibility Criteria

Inclusion Criteria

• Meet DSM-IV criteria for AN (restricting/binge-purge type) (BMI 16.0-18.5)
• Medically stable for outpatient treatment
• Availability of at least one supportive adult of choice in study client's environment
• Stable dose of psychotropic medication (8 weeks) for co-morbid condition

Exclusion Criteria

• Associated physical illness that necessitates hospitalization
• Psychotic illness or other mental illness requiring hospitalization
• Current dependence on drugs or alcohol
• Physical conditions (e.g. diabetes mellitus, pregnancy) known to influence eating or weight
• Previous Family-Based Treatment for Anorexia

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Institute of Mental Health (NIMH)

NIH

Sponsor Role: collaborator

Temple University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Eunice Y Chen, PhD

Role: PRINCIPAL_INVESTIGATOR

Temple University

Locations

Temple University

Philadelphia, Pennsylvania, United States

Countries

United States

References

Chen EY, Weissman JA, Zeffiro TA, Yiu A, Eneva KT, Arlt JM, Swantek MJ. Family-Based Therapy for Young Adults with Anorexia Nervosa Restores Weight. Int J Eat Disord. 2016 Jul;49(7):701-7. doi: 10.1002/eat.22513. Epub 2016 Apr 1.

Reference Type: RESULT

PMID: 27037965 (View on PubMed)

Related Links

http://sites.temple.edu/tedp

For More Information About The Study

Other Identifiers

R34MH083914-01

Identifier Type: NIH

Identifier Source: secondary_id

View Link

20550

Identifier Type: -

Identifier Source: org_study_id