Impacts of Superselective Infarct-related Artery (IRA) Infusion of Tirofiban on Myocardial Reperfusion and Bleeding Complications in Acute Myocardial Infarction (AMI) Patients

NCT ID: NCT01181388

Last Updated: 2010-08-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-04-30

Study Completion Date

2012-10-31

Brief Summary

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Superselective IRA infusion of tirofiban may improve myocardial reperfusion and reduce bleeding complications in AMI patients.

Detailed Description

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Conditions

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Myocardial Infarction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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intra-guide-catheter infusion of tirofiban

Group Type ACTIVE_COMPARATOR

administration of tirofiban by guide catheter

Intervention Type PROCEDURE

a bolus of 10ug/kg tirofiban administration via guide catheter followed by 0.1ug/kg/min for 12 hours after PCI

intra-thrombus-aspiration-catheter infusion of tirofiban

Group Type EXPERIMENTAL

administration of tirofiban by thrombus aspiration catheter in infarct-related artery

Intervention Type PROCEDURE

a bolus of 10ug/kg tirofiban administration via thrombus aspiration catheter followed by 0.1ug/kg/min for 12 hours after PCI

Interventions

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administration of tirofiban by thrombus aspiration catheter in infarct-related artery

a bolus of 10ug/kg tirofiban administration via thrombus aspiration catheter followed by 0.1ug/kg/min for 12 hours after PCI

Intervention Type PROCEDURE

administration of tirofiban by guide catheter

a bolus of 10ug/kg tirofiban administration via guide catheter followed by 0.1ug/kg/min for 12 hours after PCI

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* STEMI patients
* chest pain for less than 12hr
* plan to PCI

Exclusion Criteria

* LM lesion
* stent thrombosis
* cardiac shock
* thrombocytopenia
* allergy to asprin
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Beijing Anzhen Hospital

OTHER

Sponsor Role lead

Responsible Party

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the 28th Division, Beijing Anzhen Hospital

Locations

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the 28th division, Beijing Anzhen Hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Shaoping Wang, MD, PhD

Role: CONTACT

+861064456995

Yunpeng Chi, MD

Role: CONTACT

+861064456541

Facility Contacts

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Shaoping Shaoping, MD. PhD

Role: primary

+861064456995

Yunpeng Chi, MD

Role: backup

+861064456541

Other Identifiers

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64456541

Identifier Type: -

Identifier Source: org_study_id

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