Primary Prevention of Major Adverse Cardiac Events (MACE) With Standard and Intensive Statin Treatment in Patients With Diabetes: Survival and Cardiovascular Event Assessments

NCT ID: NCT01173939

Last Updated: 2011-06-01

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: NA
• Total Enrollment: 10000 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-07-31

Brief Summary

The study is being conducted to compare the effect of standard treatment (target LDL-C level: <120 mg/dL (JASGL 2007 target level)) and intensive treatment (target LDL-C level: <70 mg/dL) in the prevention of major adverse cardiac events (MACE) in hypercholesterolemia patients with concomitant type 2 diabetes and hypertension.

Conditions

Hypercholesterolemia; Type 2 Diabetes; Hypertension

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Active comparator: Standard Pravastatin Group

Group Type: ACTIVE_COMPARATOR

Pravastatin

Intervention Type: DRUG

5 mg/day or 10 mg/day of pravastatin will be administered orally for 36 months, with a follow-up period of one month. If the target LDL-C level is not attained after one month of treatment, the steps will be taken to reduce the LDL-C to the target level of \<120 mg/dL (JASGL 2007 target level) as quickly as possible. (Maximum dose increase of pravastatin: 20 mg/day)

Intensive Rosuvastatin Group

Group Type: ACTIVE_COMPARATOR

Rosuvastatin

Intervention Type: DRUG

5 mg/day or 10 mg/day of rosuvastatin will be administered orally for 36 months based on the LDL-C level of the subject, with a follow-up period of one month. If the target LDL-C level is not attained after one month of treatment, the steps will be taken to reduce the LDL-C to the target level of \<70 mg/dL as quickly as possible. (Maximum dose increase to rosuvastatin: 20 mg/day)

Interventions

Pravastatin

5 mg/day or 10 mg/day of pravastatin will be administered orally for 36 months, with a follow-up period of one month. If the target LDL-C level is not attained after one month of treatment, the steps will be taken to reduce the LDL-C to the target level of \<120 mg/dL (JASGL 2007 target level) as quickly as possible. (Maximum dose increase of pravastatin: 20 mg/day)

Intervention Type: DRUG

Rosuvastatin

5 mg/day or 10 mg/day of rosuvastatin will be administered orally for 36 months based on the LDL-C level of the subject, with a follow-up period of one month. If the target LDL-C level is not attained after one month of treatment, the steps will be taken to reduce the LDL-C to the target level of \<70 mg/dL as quickly as possible. (Maximum dose increase to rosuvastatin: 20 mg/day)

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Patients giving voluntary written consent to participate in the study

2. Male or female patients 50 years of age or older (at informed consent)

3. Hypercholesterolemia patients (Untreated patients: LDL-C level ≥140 mg/dL; treated patients: LDL-C level ≥120 mg/dL)

4. Type 2 diabetes patients (HbA1c level ≥6.1% (JDS criteria), with or without history of drug therapy)

5. Hypertension patients (SBP ≥130 mmHg or DBP ≥80 mmHg, with or without history of drug therapy)

6. Patients with two or more of the following risk factors

• Male
• 65 years of age or older
• Smoker
• L/H ratio: ≥3.0 •HbA1c level: ≥8.0%
• Left ventricular hypertrophy
• First- or second-degree family history of MACE
• Microalbuminuria (quantitative testing: ≥30 mg/dL), proteinuria (qualitative testing: + or higher) or eGFR (<60 mL/min/1.73 m2)

Exclusion Criteria

Patients meeting the following criteria will be excluded from the study:

1. Patients receiving rosuvastatin, pitavastatin, or atorvastatin therapy within one month prior to informed consent

2. Patients judged to have familial hypercholesterolemia

3. Patients with a serum triglyceride level of ≥400 mg/dL

4. Patients with a history of myocardial infarction

5. Patients with a history of coronary revascularization (PCI or CABG)

6. Patients with a history of treatment of unstable angina

7. Patients with a history of cerebrovascular accident (excluding asymptomatic lacunar infarction)

8. Heart failure patients

9. Patients with a history of hypersensitivity to statins

10. Patients with a history of drug-induced myopathy

11. Patients with poorly controlled arrhythmia

12. Patients with severe liver or kidney disease

13. Patients with serious concurrent disease, such as malignancy, or patients with severely limited lifespan

14. Patients who are or may be pregnant

15. Patients judged by the investigators to be ineligible for participation in the study for any other reason

• Minimum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Positive Trial Group

OTHER

Sponsor Role: lead

Responsible Party

Department of Cardiovascular Medicine, Faculty of Graduate School of Medical Sciences, Kumamoto University

Locations

Hiramitsu Heart Clinic

Nagoya, Aichi Pref., Japan

Medical Dock&Clinic

Nagoya, Aichi Pref., Japan

Matsuno Medical Clinic

Iyo Gun, Ehime Pref., Japan

Ishite Matsumoto Naika Junkanki Clinic

Matsuyama, Ehime Pref., Japan

Ehime Medical CO-OP Izumigawa Clinic

Niihama, Ehime Pref., Japan

Tsugawa Internal Medicine Clinic

Echizen, Fukui Pref., Japan

Fukui Chuo Clinic

Fukui, Fukui Pref., Japan

Koshino Clinic

Sakai, Fukui Pref., Japan

Fukuoka University Chikushi Hospital

Chikushino-shi, Fukuoka Pref., Japan

Saiseikai Futsukaichi Hospital

Chikushino-shi, Fukuoka Pref., Japan

Abies Clinic

Fukuoka, Fukuoka Pref., Japan

Hirano Medical Clinic

Fukuoka, Fukuoka Pref., Japan

Naitoh Clinic

Fukuoka, Fukuoka Pref., Japan

Saku Hospital

Fukuoka, Fukuoka Pref., Japan

Fukuoka Tokushukai Medical Center

Kasuga, Fukuoka Pref., Japan

Morizono Naika

Kitakyushu, Fukuoka Pref., Japan

Kawai Naika Clinic

Gifu, Gifu Pref., Japan

Hiroshima General Hospital of West Japan Railway Company

Hiroshima, Hiroshima Pref., Japan

Hijirigaoka Hospital

Date, Hokkaido Pref., Japan

Kyoaikai Hospital

Hakodate, Hokkaido Pref., Japan

Miyazawa Cardiovascular And Internal Medicine Clinic

Kato-gun, Hokkaido Pref., Japan

Jiyugaoka Yamada Clinic

Obihiro, Hokkaido Pref., Japan

Chikama Clinic

Sapporo, Hokkaido Pref., Japan

Hiro Clinic

Sapporo, Hokkaido Pref., Japan

Medical and Radiology Clinic Caress Sapporo Hokko Memorial Hospital

Sapporo, Hokkaido Pref., Japan

Seiwa Memorial Hospital

Sapporo, Hokkaido Pref., Japan

Medical Treatment Corporate Foundation Yubari Kibounomori Yubari City Clinic

Yūbari, Hokkaido Pref., Japan

Ino Hospital

Himeji, Hyogo Pref., Japan

Katsuya Clinic

Amagasaki, Hyogo Pref, Japan

Kotani Diabetes Clinic

Kobe, Hyogo Pref, Japan

Shimizu Clinic

Kobe, Hyogo Pref, Japan

Dr. Kodama's Office of Internal Medicine

Nishinomiya, Hyogo Pref, Japan

Koga Hospital

Koga, Ibaraki Pref., Japan

Imura Internal Medicine Clinic

Hakusan, Ishikawa Pref., Japan

Yanagi Medical Clinic

Hakusan, Ishikawa Pref., Japan

Okyozuka Clinic

Ishikawa Gun, Ishikawa Pref., Japan

Koni Clinic

Kahoku Gun, Ishikawa Pref., Japan

Murata Clinic

Kahoku Gun, Ishikawa Pref., Japan

Arai Naika Clinic

Kanazawa, Ishikawa Pref., Japan

Dr. Hayakawa's Family Clinic

Kanazawa, Ishikawa Pref., Japan

Wakasa Medical Clinic

Kanazawa, Ishikawa Pref., Japan

Morita Hospital

Komatsu, Ishikawa Pref., Japan

Kawasaki Family Clinic

Ichinoseki, Iwate Pref., Japan

Sugie Clinic

Iwate Gun, Iwate Pref., Japan

Katsura General Clinic

Morioka, Iwate Pref., Japan

Takamiya General Clinic

Shiwa Gun, Iwate Pref., Japan

Hayashi Clinic

Marugame, Kagawa Pref., Japan

Otsuka Internal Medicine Clinic

Marugame, Kagawa Pref., Japan

Center for Preventive Medical Treatment, NTT West Takamatsu Hospital

Takamatsu, Kagawa Pref., Japan

Hananomiya Clinic

Takamatsu, Kagawa Pref., Japan

Hasegawa Outpatients Clinic for Cardiovascular Disease

Takamatsu, Kagawa Pref., Japan

Kojima Clinic

Takamatsu, Kagawa Pref., Japan

Matsuoka Clinic

Takamatsu, Kagawa Pref., Japan

Osumi-Kanoya Hospital

Kanoya, Kagoshima Pref., Japan

Yakushima Tokushukai Hospital

Kumage Gun, Kagoshima Pref., Japan

Nemoto G.I.M. Clinic

Ashigara-kami Gun, Kanagawa Pref., Japan

Magokoro Internal Medicine and Orthopedic Clinic

Ashigarakami Gun, Kanagawa Pref., Japan

Kasuya Clinic

Atsugi, Kanagawa Pref., Japan

Kuboshima Clinic

Fujisawa, Kanagawa Pref., Japan

Takahashi Clinic

Fujisawa, Kanagawa Pref., Japan

Akizawa Clinic

Isehara, Kanagawa Pref., Japan

Medical Corp Takeda Clinic

Isehara, Kanagawa Pref., Japan

Hashimoto Clinic

Kamakura, Kanagawa Pref., Japan

Iroden Clinic

Kamakura, Kanagawa Pref., Japan

Kamakura Naika Shinryosyo

Kamakura, Kanagawa Pref., Japan

Shohei Clinic

Kamakura, Kanagawa Pref., Japan

Hatori Medical Clinic

Kawasaki, Kanagawa Pref., Japan

Hirayasu Iin

Kawasaki, Kanagawa Pref., Japan

Kamegaya Medical Clinic

Kawasaki, Kanagawa Pref., Japan

Kirimura Iin

Kawasaki, Kanagawa Pref., Japan

Kojima Clinic

Odawara, Kanagawa Pref., Japan

Hakuai Iin

Sagamihara, Kanagawa Pref., Japan

Sato Clinic

Sagamihara, Kanagawa Pref., Japan

Toshiba Rinkan Hospital

Sagamihara, Kanagawa Pref., Japan

Yamamoto Clinic

Sagamihara, Kanagawa Pref., Japan

Fukumura Clinic

Yokohama, Kanagawa Pref., Japan

Fukushi Clinic

Yokohama, Kanagawa Pref., Japan

International Goodwill Hospital

Yokohama, Kanagawa Pref., Japan

Kikuchi Clinic

Yokohama, Kanagawa Pref., Japan

Matsuo Naika Clinic

Yokohama, Kanagawa Pref., Japan

Miho-cho Cardiovascular Medical Clinic

Yokohama, Kanagawa Pref., Japan

Minamisawa Clinic

Yokohama, Kanagawa Pref., Japan

Miyoshi-Clinic

Yokohama, Kanagawa Pref., Japan

Paula's Clinic

Yokohama, Kanagawa Pref., Japan

Shimokurata Heart Clinic

Yokohama, Kanagawa Pref., Japan

Shinwakai Fukuda Iin

Yokohama, Kanagawa Pref., Japan

Shinyoshida Clinic

Yokohama, Kanagawa Pref., Japan

Suzuki Orthopedic Clinic

Yokohama, Kanagawa Pref., Japan

Yokohama City University Medical Center

Yokohama, Kanagawa Pref., Japan

Yokohama Sotetsu bldg. clinic of internal medicine

Yokohama, Kanagawa Pref., Japan

Hara Clinic

Yokosuka, Kanagawa Pref., Japan

Ueta Medical Clinic

Kochi, Kochi Pref., Japan

Nakayama Cardiovascular Clinic

Amakusa, Kumamoto Pref., Japan

Yamashita Clinic

Amakusa, Kumamoto Pref., Japan

National Health Insurance Central Hospital Aso

Aso, Kumamoto Pref., Japan

Sakanashi Heart Clinic

Aso, Kumamoto Pref., Japan

Koyasako iin

Kamimashiki Gun, Kumamoto Pref., Japan

Kawaguchi Hospital

Kikuchi, Kumamoto Pref., Japan

Miyamoto Internal Clinic

Kikuchi, Kumamoto Pref., Japan

Doi Cardiovascular Clinic

Kumamoto, Kumamoto Pref., Japan

Doi Naika-ichoka Clinic

Kumamoto, Kumamoto Pref., Japan

Haraguchi Circular&Internal Medical Clinic

Kumamoto, Kumamoto Pref., Japan

Jinnouchi Clinic Diabetes Care Center

Kumamoto, Kumamoto Pref., Japan

Kiyota Junkanki Naika Iin

Kumamoto, Kumamoto Pref., Japan

Maki Cardiovascular Clinic

Kumamoto, Kumamoto Pref., Japan

Nozuhara Clinic

Kumamoto, Kumamoto Pref., Japan

Ootsuka Hospital

Kumamoto, Kumamoto Pref., Japan

Shono Heart Clinic

Kumamoto, Kumamoto Pref., Japan

Suefuji Naika Junkankika

Kumamoto, Kumamoto Pref., Japan

Suizenji Tohya Hospital

Kumamoto, Kumamoto Pref., Japan

Terao Hospital

Kumamoto, Kumamoto Pref., Japan

Yi Medical Clinic

Kumamoto, Kumamoto Pref., Japan

Munakata Clinic

Shimomashiki Gun, Kumamoto Pref., Japan

Higashi Diabetes and Cardiovascular Clinic

Tamana, Kumamoto Pref., Japan

Yoshimura Jyunnkannkika Naika Iinn

Tamana, Kumamoto Pref., Japan

Universal Shipbuilding Co. Ariake Shipyard Ariake Infirmary

Tamana Gun, Kumamoto Pref., Japan

Miyagi Clinic Cardiovascular Medicine

Yatsushiro, Kumamoto Pref., Japan

Koide Iin

Kizugawa, Kyoto Pref., Japan

Asamoto Clinic of Internal Medicine

Kyoto, Kyoto Pref., Japan

Gotoh Clinic

Kyoto, Kyoto Pref., Japan

Higashiyama Takeda Hospital

Kyoto, Kyoto Pref., Japan

Isoda Internal Medical Clinic

Kyoto, Kyoto Pref., Japan

Omoto Clinic

Kyoto, Kyoto Pref., Japan

Sakazaki Clinic

Kyoto, Kyoto Pref., Japan

Shinya Clinic

Kyoto, Kyoto Pref., Japan

Takagi Cardiology Clinic

Kyoto, Kyoto Pref., Japan

Takenaka Clinic

Kyoto, Kyoto Pref., Japan

Tegoshi Clinic

Kyoto, Kyoto Pref., Japan

Sawai medical Clinic

Kyōtanabe, Kyoto Pref., Japan

Kimura Naika Clinic

Yosa Gun, Kyoto Pref., Japan

Shimizu Clinic

Ise, Mie Pref., Japan

Horii Clinic Kiodai

Nabari, Mie Pref., Japan

Yamoto-naika Clinic

Higashi Matsushima City, Miyagi Pref., Japan

Seisuikai Yoshioka QQ Clinic

Kurokawa Gun, Miyagi Pref., Japan

Ohtomo Clinic

Tome, Miyagi Pref., Japan

Shimoina Kosei Hospital

Shimoina Gun, Nagano Pref., Japan

Yokoyama Medical Clinic

Shiojiri, Nagano Pref., Japan

Sato Clinic

Suzaka, Nagano Pref., Japan

Hoshiko Clinic

Nagasaki, Nagasaki Pref., Japan

Shinagawa Clinic

Nagasaki, Nagasaki Pref., Japan

Iryohojin Yamamoto Naika

Nishisonogi Gun, Nagasaki Pref., Japan

Yamada Clinic

Gojō, Nara Pref., Japan

Uyama Naika Clinic

Ikoma, Nara Pref., Japan

Clinic Jinguumae

Kahihara City, Nara Pref., Japan

Kasahara Clinic

Kahihara City, Nara Pref., Japan

Sawada Clinic

Kashiba, Nara Pref., Japan

Doi Clinic

Kashihara, Nara Pref., Japan

Medical Corporation Kiriyama Clinic

Kashihara, Nara Pref., Japan

Miyamoto Clinic

Kashihara, Nara Pref., Japan

Oosumi Naika Iin

Kashihara, Nara Pref., Japan

Kondo Clinic Mamigaoka Purified Center

Kitakatsuragi Gun, Nara Pref., Japan

Matsuoka Clinic

Kitakatsuragi Gun, Nara Pref., Japan

Nakahori Iin

Kitakatsuragi Gun, Nara Pref., Japan

Seiwadai Clinic

Kitakatsuragi Gun, Nara Pref., Japan

Saiseikai Nara Hospital

Nara, Nara Pref., Japan

Takanohara Central Hospital

Nara, Nara Pref., Japan

Takanohara Suzuran-naika

Nara, Nara Pref., Japan

Ote Clinic of Internal Medicine

Sakurai, Nara Pref., Japan

Sakaguchi Clinic

Sakurai, Nara Pref., Japan

Kokuho Central Hospital

Shiki Gun, Nara Pref., Japan

Makiura Naika

Yamatokōriyama, Nara Pref., Japan

Matsuta Heart Clinic

Yamatokōriyama, Nara Pref., Japan

Nakatani Clinic

Yamatotakada City, Nara Pref., Japan

Sano Clinic

Murakami, Niigata Pref., Japan

Kawaguchi Clinic

Nagaoka, Niigata Pref., Japan

Maeda Medical Clinic

Niigata, Niigata Pref., Japan

Watanabe NJ Clinic

Beppu, Oiat Pref., Japan

Hirata Clinic

Ōita, Oiat Pref., Japan

Ninomiya Clinic

Ōita, Oiat Pref., Japan

Sumi Cardiology Clinic

Ōita, Oiat Pref., Japan

Tokumaru Digestive Internal Medicine Clinic

Ōita, Oiat Pref., Japan

Tsuzaki Clinic

Ōita, Oiat Pref., Japan

Ishida Medical Clinic

Usa, Oiat Pref., Japan

Hachiouji Naika Clinic

Kurashiki, Okayama Pref., Japan

Inada Clinic

Kurashiki, Okayama Pref., Japan

Hisamatsu Medical Clinic

Okayama, Okayama Pref., Japan

Yuhara Naika Clinic

Okayama, Okayama Pref., Japan

Hattori Clinic

Setouchi, Okayama Pref., Japan

Nishimura Clinic

Fujiidera, Osaka Pref., Japan

Ikeda Clinic

Higashiosaka, Osaka Pref., Japan

Ogawa Clinic

Higashiosaka, Osaka Pref., Japan

Taisei Clinic

Hirakata, Osaka Pref., Japan

Ishiga Clinic

Ibaraki, Osaka Pref., Japan

Masuda Clinic

Ibaraki, Osaka Pref., Japan

Kanazawa Clinic

Izumi, Osaka Pref., Japan

Misugi Clinic

Kaizuka, Osaka Pref., Japan

Yoshida Clinic

Kaizuka, Osaka Pref., Japan

Mori Iin

Kishiwada, Osaka Pref., Japan

Medical Corporation Joukokai Teranishi-geka naika

Moriguchi, Osaka Pref., Japan

Iryouhoujin Suisyoukai Murata Hospital

Osaka, Osaka Pref., Japan

Izuoka Clinic

Osaka, Osaka Pref., Japan

Keiju Hospital

Osaka, Osaka Pref., Japan

Kondo Clinic

Osaka, Osaka Pref., Japan

Kubota Clinic

Osaka, Osaka Pref., Japan

Matsushita Medical Clinic

Osaka, Osaka Pref., Japan

Nishizawa Clinic

Osaka, Osaka Pref., Japan

Osaka General Medical Center

Osaka, Osaka Pref., Japan

Senpuku Clinic

Osaka, Osaka Pref., Japan

Tai Internal Medicin Clinic

Osaka, Osaka Pref., Japan

Ueda Clinic

Osaka, Osaka Pref., Japan

Ohta Iin

Sakai, Osaka Pref., Japan

Ban Clinic

Suita, Osaka Pref., Japan

Iryohojin Nogi Naika Iin

Suita, Osaka Pref., Japan

Kobayashi Clinic

Suita, Osaka Pref., Japan

Ichida Internal Clinic

Takaishi, Osaka Pref., Japan

Yada Clinic

Takaishi, Osaka Pref., Japan

Ryo Clinic

Takatsuki, Osaka Pref., Japan

Matsuo Clinic

Yao, Osaka Pref., Japan

Enomoto Clinic

Ageo, Saitama Pref., Japan

Medimo Hanyu Clinic

Hanyū, Saitama Pref., Japan

Hirose Hospital

Kawagoe, Saitama Pref., Japan

Iryohojin Hogi Shinryojo

Kawaguchi, Saitama Pref., Japan

Tokutake Iin

Kawaguchi, Saitama Pref., Japan

Gamo Tenjinbashi Clinic

Koshigaya, Saitama Pref., Japan

Matsumoto Clinic

Koshigaya, Saitama Pref., Japan

Medical Corporation Shibuya Clinic

Kumagaya, Saitama Pref., Japan

Akimoto Clinic

Saitama, Saitama Pref., Japan

Iwatsuki-minami Hospital

Saitama, Saitama Pref., Japan

Suzuhiro Clinic

Saitama, Saitama Pref., Japan

Nashida naika clinic

Tokorozawa, Saitama Pref., Japan

Shizuoka Medical Alliance Shirahama Chuou Clinic

Shimoda, Shizuoka Pref., Japan

Akiyama Clinic

Shizuoka, Shizuoka Pref., Japan

Aoshima Clinic

Shizuoka, Shizuoka Pref., Japan

Eguchi Clinic

Shizuoka, Shizuoka Pref., Japan

Shizuoka Hospital

Shizuoka, Shizuoka Pref., Japan

Ueno Clinic

Yaizu, Shizuoka Pref., Japan

Takahashi Medical Clinic

Ohtawara City, Tochigi Pref., Japan

Iryouhoujin Yuukoukai Morioka Naika Shonika

Oyama, Tochigi Pref., Japan

Takada Clinic

Tochigi, Tochigi Pref., Japan

Masuda Naika

Utsunomiya, Tochigi Pref., Japan

Murakami Clinic

Anan, Tokushima Pref., Japan

Fukushima Clinic

Itano Gun, Tokushima Pref., Japan

Yamamoto Naika Ityoka

Itano Gun, Tokushima Pref., Japan

Yuki National Health Insurance Hospital Of Minami Town

Kaifu Gun, Tokushima Pref., Japan

Sekishinkan Hospital

Komatsushima, Tokushima Pref., Japan

Ueta Clinic

Myozai Gun, Tokushima Pref., Japan

Kensei Uchimachi Clinic

Tokushima, Tokushima Pref., Japan

Kitagawa Naika Ityoka

Tokushima, Tokushima Pref., Japan

Kitasako Clinic

Tokushima, Tokushima Pref., Japan

Limbs Tokushima Clinic

Tokushima, Tokushima Pref., Japan

Matsumura Internal, Gastrointestial Medicine

Tokushima, Tokushima Pref., Japan

Okagawa Clinic

Tokushima, Tokushima Pref., Japan

Yokoi Internal Medicine

Tokushima, Tokushima Pref., Japan

Kimura Internal Medicine Clinic

Yoshinokawa City, Tokushima Pref., Japan

Yata Clinic

Yoshinokawa City, Tokushima Pref., Japan

Okubo Clinic

Akishima, Tokyo, Japan

Juntendo University Hospital

Bunkyo Ku, Tokyo, Japan

Choei Clinic

Edogawa Ku, Tokyo, Japan

Shiraishi Iin

Edogawa Ku, Tokyo, Japan

Hattori Clinic

Hachiōji, Tokyo, Japan

Toyoizumi Hospital

Hachiōji, Tokyo, Japan

Utsugidai Tajima Clinic

Hachiōji, Tokyo, Japan

Mochizuki Naika Clinic

Itabashi Ku, Tokyo, Japan

Nishio Clinic

Itabashi Ku, Tokyo, Japan

Ono Heart Clinic

Koto Ku, Tokyo, Japan

Shiba Palace Clinic

Minato-ku, Tokyo, Japan

Kamada Clinic

Mitaka, Tokyo, Japan

Tenjinmae Clinic

Mitaka, Tokyo, Japan

Takayama Iin

Mitaka-shi, Tokyo, Japan

Sugawara Clinic

Nerima Ku, Tokyo, Japan

Yamada Clinic

Ōta-ku, Tokyo, Japan

Matsumura Gastroenterological Clinic

Setagaya Ku, Tokyo, Japan

Magari Clinic

Shinjuku Ku, Tokyo, Japan

Yotsuya Internal Medicine Clinic

Shinjuku Ku, Tokyo, Japan

Yotsuya-Murakami Internal Medicine Clinic

Shinjuku Ku, Tokyo, Japan

Obayashi Clinic

Sumida City, Tokyo, Japan

Sumidagawa Clinic

Sumida Ku, Tokyo, Japan

ISHII Medical Clinic

Tachikawa-shi, Tokyo, Japan

Takahashi Ko Minako Clinic

Murayama, Yamagata Pref., Japan

Obanazawa City Clinic

Obanazawa, Yamagata Pref., Japan

Okuyama Clinic

Obanazawa, Yamagata Pref., Japan

Sakae Clinic

Obanazawa, Yamagata Pref., Japan

Honma Clinic

Sakata, Yamagata Pref., Japan

Isoda Clinic

Yamagata, Yamagata Pref., Japan

Nihei Clinic

Yamagata, Yamagata Pref., Japan

Shimasaki Clinic

Yamagata, Yamagata Pref., Japan

Yamagata Tokushukai Hospital

Yamagata, Yamagata Pref., Japan

Iwasaki Naika Iin

Iwakuni, Yamaguchi Pref., Japan

Kuwahara Clinic

Iwakuni, Yamaguchi Pref., Japan

Ayame Medical Clinic

Shimonoseki, Yamaguchi Pref., Japan

Johno Clinic

Shimonoseki, Yamaguchi Pref., Japan

Matsuda Medical Clinic

Shimonoseki, Yamaguchi Pref., Japan

Mizumachi Medical Clinic

Shimonoseki, Yamaguchi Pref., Japan

Noda Clinic

Shimonoseki, Yamaguchi Pref., Japan

Fujii Clinic

Ube, Yamaguchi Pref., Japan

Shakaiiryouhoujin Onaka Hospital

Ube, Yamaguchi Pref., Japan

Watada-naika Hospital

Ube, Yamaguchi Pref., Japan

Ouchi Clinic

Yamaguchi, Yamaguchi Pref., Japan

Yoshizaki Clinic

Chūō, Yamanashi Pref., Japan

Takahashi Clinic

Nishi Yatsushiro Gun, Yamanashi Pref., Japan

Higashikatsura Medical Clinic

Tsuru, Yamanashi Pref., Japan

Fukushi Clinic

Aomori, , Japan

Kashiwagi Clinic

Ayase, , Japan

Hayashi Diabetes Clinic

Chigasaki, , Japan

Uchiyama Clinic

Jōetsu, , Japan

Nitta Medical Clinic

Kamiinagun, , Japan

Imai Clinic

Kawasaki, , Japan

Tani Clinic

Kitakyushu, , Japan

Marumo Clinic

Koganei, , Japan

Ihara Clinic

Kyoto, , Japan

Goko-Hospital

Matsudo, , Japan

Satou Clinic

Mooka, , Japan

Iino Clinic

Nirasaki, , Japan

Miura Clinic

Osaka, , Japan

Kuroda Iin

Ōtsuki, , Japan

Sasaki Clinic

Sendai, , Japan

Kamata Clinic of Internal Medicine

Shiki, , Japan

Nishikawa Clinic

Shimoda, , Japan

Satou Iin

Shimoinagun, , Japan

Kumagai Clinic

Shinshiro, , Japan

Suzuki Clinic

Toyokawa, , Japan

Benibana Clinic

Yamagata, , Japan

Fujimi Clinic

Yokohama, , Japan

Hongo Clinic

Yokohama, , Japan

Jiyukai Yamada Naika

Yokohama, , Japan

Shonan Ochanomizu Clinic

Yokohama, , Japan

Tani Clinic Internal Medicine, Allergology & Rheumatology

Yokohama, , Japan

Countries

Japan

Other Identifiers

0035

Identifier Type: -

Identifier Source: org_study_id