Evaluation of the Efficacy and Safety of Rosuvastatin 5 mg Versus Pravastatin 40 mg and Atorvastatin 10 mg in Type IIa and IIb Hypercholesterolaemic Patients

NCT ID: NCT00631189

Last Updated: 2013-11-26

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

668 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-10-31

Study Completion Date

2008-10-31

Brief Summary

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The purpose of this study is to evaluate the efficacy and safety of Rosuvastatin 5 mg as an hypercholesterolemia treatment comparatively at 2 other statins: Pravastatin 40 mg and Atorvastatin 10 mg. Treatment efficacy will be evaluated by the percentage of LDL-C variation after 8 weeks of treatment.

Detailed Description

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Conditions

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Type IIa and IIb Hypercholesterolaemia

Keywords

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dyslipidemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

Rosuvastatin and Pravastatin

Group Type ACTIVE_COMPARATOR

Rosuvastatin

Intervention Type DRUG

5mg oral

Pravastatin

Intervention Type DRUG

40mg oral

2

Rosuvastatin and Atorvastatin

Group Type ACTIVE_COMPARATOR

Rosuvastatin

Intervention Type DRUG

5mg oral

Atorvastatin

Intervention Type DRUG

10mg oral

Interventions

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Rosuvastatin

5mg oral

Intervention Type DRUG

Pravastatin

40mg oral

Intervention Type DRUG

Atorvastatin

10mg oral

Intervention Type DRUG

Other Intervention Names

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Crestor Prevachol Lipitor

Eligibility Criteria

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Inclusion Criteria

* subjects presenting type IIa or IIb primary hypercholesterolaemia diagnosed for at least 3 months, in a context of primary prevention with at least two associated cardiovascular risk factors and: (i)either "naive" to all lipid-lowering therapy, (ii)or treated with a statin (treatment ongoing or stopped during the previous 8 weeks)

Exclusion Criteria

* homozygous or heterozygous familial hypercholesterolaemia
* hypertriglyceridaemia (TG ≥ 4 g/l)
* subjects at high cardiovascular risk according to the AFSSAPS 2005 definition (coronary artery disease or history of documented vascular disease, high cardiovascular risk type 2 diabetes, subject in primary prevention with a 10-year CHD risk \> 20%)
* history of adverse events or hypersensitivity to an HMG Co-A reductase inhibitor (particularly a history of myopathy)
* concomitant use of any drugs not authorized during the study
* active liver disease with elevation of serum transaminases (ASAT, ALAT) more than twice the upper limit of normal
* CPK more than 3 times the upper limit of normal
* moderate or severe renal failure (creatinine clearance \< 6 ml/min)
* poorly controlled hypothyroidism; poorly controlled hypertension (DBP \> 95 mm Hg and/or SBP \> 180 mm Hg)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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AstraZeneca

Principal Investigators

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Michel Farnier, MD

Role: PRINCIPAL_INVESTIGATOR

Le Point Medical - Rond Point du Jour

Locations

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Aix-en-Provence, , France

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Allaire, , France

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Amiens, , France

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Ancerville, , France

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Angers, , France

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Annecy, , France

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Anzin, , France

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Arles, , France

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Arthez-de-Béarn, , France

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Aspach-le-Bas, , France

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Aubagne, , France

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Auchel, , France

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Bailleul, , France

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Balma, , France

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Beaucaire, , France

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Belfort, , France

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Bersée, , France

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Bézenet, , France

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Béziers, , France

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Biarritz, , France

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Blois, , France

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Bondues, , France

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Bondy, , France

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Bordeaux, , France

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Brignoud, , France

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Bruay-la-Buissière, , France

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Bruges, , France

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Bœrsch, , France

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Cabanac-et-Villagrains, , France

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Cadaujac, , France

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Caen, , France

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Cannes La Bocca, , France

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Carnon-Plage, , France

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Caylus, , France

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Cernay, , France

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Cestas, , France

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Champcueil, , France

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Chanceaux-sur-Choisille, , France

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Chilly-Mazarin, , France

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Clary, , France

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Collioure, , France

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Colombier-Fontaine, , France

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Colomiers, , France

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Coulonieix Chamiers, , France

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Crécy-la-Chapelle, , France

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Crotenay, , France

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Cuise-la-Motte, , France

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Derval, , France

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Dijon, , France

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Eckbolsheim, , France

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Eckwersheim, , France

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Épernay, , France

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Épinal, , France

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Étang-sur-Arroux, , France

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Évreux, , France

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Fargues-Saint-Hilaire, , France

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Folembray, , France

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Fos-sur-Mer, , France

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Franconville, , France

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Gamarde-les-Bains, , France

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Gambsheim, , France

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Gradignan, , France

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Grand-Couronne, , France

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Grendelbruch, , France

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Guise, , France

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Harnes, , France

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Horbourg-Wihr, , France

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Is-sur-Tille, , France

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Ivry-sur-Seine, , France

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Jarville-la-Malgrange, , France

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Jeumont, , France

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La Ciotat, , France

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La Courneuve, , France

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La Crèche, , France

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La Francheville, , France

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Lacrouzette, , France

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Lamagistère, , France

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Laval, , France

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Le Bouscat, , France

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Le Cannet, , France

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Le Passage, , France

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Les Issambres, , France

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Léognan, , France

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Lille, , France

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Lucheux, , France

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Marcq-en-Barœul, , France

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Marseille, , France

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Maslacq, , France

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Mauguio, , France

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Meaux-beauval, , France

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Mennecy, , France

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Mensignac, , France

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Merlimont, , France

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Metz, , France

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Miramont-de-Guyenne, , France

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Mittersheim, , France

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Monfort En Chalosse, , France

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Monguilhem, , France

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Mont-de-Marsan, , France

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Montauroux, , France

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Montbéliard, , France

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Monteux, , France

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Montfrin, , France

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Montigny-lès-Metz, , France

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Montpellier, , France

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Moreuil, , France

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Muespach, , France

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Nancy, , France

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Nogent-sur-Marne, , France

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Noyon, , France

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Oberhausbergen, , France

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Orchamps, , France

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Palau-del-Vidre, , France

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Paris, , France

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Pau, , France

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Pauillac, , France

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Périgueux, , France

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Pfulgriesheim, , France

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Phalempin, , France

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Pont-à-Mousson, , France

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Pouilly-en-Auxois, , France

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Poussan, , France

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Pradines, , France

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Puteaux, , France

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Quimperlé, , France

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Rognac, , France

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Rohrwiller, , France

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Roncq, , France

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Roquevaire, , France

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Roubaix, , France

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Saint-Etienne, , France

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Saint-Émilion, , France

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Saint-Étienne-de-Montluc, , France

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Saint-Girons, , France

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Saint-Jean-de-Braye, , France

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Saint-Leu-la-Forêt, , France

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Saint-Martin-d'Oney, , France

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Saint-Médard-en-Jalles, , France

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Saint-Morillon, , France

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Saint-Rémy, , France

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Saint-Rémy-de-Provence, , France

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Salles, , France

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Sarlat-la-Canéda, , France

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Semur-en-Auxois, , France

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Serres-Castet, , France

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Soissons, , France

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Sorcy-Saint-Martin, , France

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Strasbourg, , France

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Tarare, , France

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Targon, , France

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Tartas, , France

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Tassin-la-Demi-Lune, , France

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Thônes, , France

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Thun-Saint-Amand, , France

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Toulon, , France

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Toulouse, , France

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Trie-sur-Baïse, , France

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Varces-Allières-et-Risset, , France

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Vatan, , France

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Vence, , France

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Vélizy-Villacoublay, , France

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Vieux-Boucau-les-Bains, , France

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Villard-Bonnot, , France

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Villette-d'Anthon, , France

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Viry-Châtillon, , France

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Wasselonne, , France

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Wattignies, , France

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Wattrelos, , France

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Yerres, , France

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Yffiniac, , France

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Countries

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France

Other Identifiers

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EudraCT No 2006-006697-15

Identifier Type: -

Identifier Source: secondary_id

D3560L00068

Identifier Type: -

Identifier Source: org_study_id