Repetitive Transcranial Stimulation (rTMS) for Resistant Depression in Adolescents
NCT ID: NCT01170520
Last Updated: 2012-01-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE1/PHASE2
24 participants
INTERVENTIONAL
2010-08-31
Brief Summary
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A group of adolescents suffering from non psychotic major depression that was resistant to at least 2 drug trials and a trail of psychotherapy will be recruited. After an informed consent procedure for both parents and patients, patients will go through a clinical and cognitive evaluation. They will receive a protocol of 4 weeks (20 work days) of rTMS using the figure of 8 magstim coil at 100% threshold, 42 trains of 4 seconds each, intertrain interval of 30 sec to the LDPC, 1680 pulses per day. Then they will be reevaluated.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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rTMS
repetitive transcranial Stimulation
rTMS using the figure of 8 magstim for 4 weeks or 20 work days, using 100% threshold to the LDPFC 42 trains per day 4 sec pretrain inter train interval of 30 sec.
Interventions
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repetitive transcranial Stimulation
rTMS using the figure of 8 magstim for 4 weeks or 20 work days, using 100% threshold to the LDPFC 42 trains per day 4 sec pretrain inter train interval of 30 sec.
Eligibility Criteria
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Inclusion Criteria
* Right hand dominant
* Suffering from major depression
* CDRS \> 60
* At least 3 months of current depressive episode
* Failed 2 drug trials (or 3 drug trials if trial terminated prematurely due to side effects) and at least 1 course of psychotherapy
* No contraindication for rtms (safety questionnaire)
* No change in pharmacotherapy in the last month
Exclusion Criteria
* Hypertension
* Epilepsy
* History of major head trauma
* Metal implements in the head
* History of neurosurgery
* History of severe head migraine
* History of hearing loss or sp cochlear transplantation
* Pregnancy
* Current drug abuse
* Unstable medical condition
* History of manic episode
* Current treatment with lithium or tricyclic or tetracyclic antidepressants
15 Years
18 Years
ALL
No
Sponsors
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Shalvata Mental Health Center
OTHER
Responsible Party
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Locations
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Shalvata Mental health Center
Hod HaSharon, , Israel
Shalvata Mental Health Center
Hod HaSharon, , Israel
Countries
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Central Contacts
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Facility Contacts
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Yuval Bloch, MD
Role: primary
Other Identifiers
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HT 4953
Identifier Type: -
Identifier Source: org_study_id
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