Study of Cytochrome P450 Polymorphisms (CYP2D6, CYP3A4/5 and CYP2C19) in Breast Cancer Patients
NCT ID: NCT01169792
Last Updated: 2010-07-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
OBSERVATIONAL
Brief Summary
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The investigators want to
* evaluate the frequency or incidence of the genetic polymorphisms of cytochrome P450 subfamilies(CYP2D6, CYP3A4/5 and CYP2C19) in breast cancer patients, and
* analyze the association between the genetic polymorphisms of cytochrome P450 subfamilies and clinical outcomes in breast cancer patients treated by adjuvant tamoxifen therapy.
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Breast cancer patients
Breast cancer patients who underwent surgery with or without chemotherapy, endocrine therapy and/or radiation therapy. The patients are categorized according to the genetic polymorphisms or the activity score of the cytochrome P450 metabolism.
tamoxifen
Interventions
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tamoxifen
Eligibility Criteria
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Inclusion Criteria
* Breast cancer patients who underwent surgery
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Inje University
OTHER
Yonsei University
OTHER
Principal Investigators
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Byeong-Woo Park, M.D.,ph.D.
Role: STUDY_CHAIR
Department of Surgery and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine
Jae-Gook Shin, M.D.,ph.D.
Role: STUDY_CHAIR
Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine
Locations
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Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine
Jin-Gu, Busan, South Korea
Department of Surgery, Yonsei University College of Medicine
Saedaemoon-gu, Seoul, South Korea
Countries
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Other Identifiers
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4-2009-0483
Identifier Type: -
Identifier Source: org_study_id
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