Aromatase (CYP19) Polymorphism Between AI-responsive and AI-resistant Breast Cancer in Korea

NCT ID: NCT01137136

Last Updated: 2014-04-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

SUSPENDED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-06-30

Study Completion Date

2015-12-31

Brief Summary

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Aromatase(CYP19)inhibitor is one of the major antihormonal drug for breast cancer in postmenopausal women. The variation of CYP19 may affect the effect of aromatase inhibitor. However, the incidence of variation of CYP19 in Korea has not known. Therefore, the investigators want to know the incidence of variation of CYP19 and to assess the effect of these variations of CYP19 to aromatase inhibitor users.

Detailed Description

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Conditions

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Polymorphism CYP19 Aromatase Inhibitor

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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SMAC (SMc AI user Cohort)

All patients who took the AI (Aromatase inhibitor)will be enrolled

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* hormone receptor positiveBreast cancer patient
* postmenopausal women
* first user of aromatase inhibitor

Exclusion Criteria

* premenopausal
* The patient who take the other antihormonal therapy
* osteoporosis patients
Maximum Eligible Age

80 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Samsung Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Seok Jin Nam

Professor, M.D., Ph.D.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Seok Jin Nam, M.D., Ph.D.

Role: STUDY_DIRECTOR

Samsung Medical Center, Sungkyunkwan University School of Medicine, Department of Surgery

Locations

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Samsung Medical Center

Seoul, Seoul, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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2009-11-035

Identifier Type: -

Identifier Source: org_study_id

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