Evaluation of the Reproducibility of Jumping Mechanography

NCT ID: NCT01164670

Last Updated: 2015-10-05

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 96 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2010-05-31
• Study Completion Date: 2011-03-31

Brief Summary

Sarcopenia, the age-related decline in muscle mass and function (widely recognized as "frailty"), is increasingly being appreciated, primarily in the research environment. Interventions to prevent or treat sarcopenia can be anticipated to reduce falls, fractures and thereby to facilitate independence and improve quality of life for older adults. Unfortunately, there is no current consensus definition of sarcopenia, thereby impeding clinical recognition and treatment. It has been advocated that low appendicular (arm and leg) lean mass, as measured by DXA, be utilized as a clinical diagnostic tool to define sarcopenia. While such an approach is possible, however, muscle strength loss is more rapid than mass loss, indicating deterioration of muscle "quality." Muscle quality may be affected by changes at the neuromuscular, cellular or subcellular levels; parameters not detected by measuring mass alone. Clearly, tools evaluating muscle performance, not simply mass, are needed to optimally identify, and subsequently monitor, treatment of older adults with sarcopenia. While current tests of muscle power/function (e.g., chair-rising, self-selected gait velocity, etc.) do correlate with functional limitation in older adults, these existing tests have limitations in that they cannot be performed in all people, may have "yes/no" results rather than a continuous scale and may not be highly precise. Thus, improved muscle function assessment tools are needed, both clinically and in research venues. Jumping mechanography is very likely one such methodology.

Conditions

Sarcopenia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Men

Men over 70 years old.

No interventions assigned to this group

Women

Women over 70 years old.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Ambulatory, community dwelling men and women age ≥ 70 years
• Able and willing to sign informed consent
• Able to stand without assistance

Exclusion Criteria

• Abnormalities on screening laboratory assessment deemed to be clinically significant by the study investigators
• History of myocardial infarction within the prior six months or ongoing angina
• History of injury or surgery within the prior six months which limits the ability to ambulate
• History of severe end-organ disease, e.g., cardiovascular, hepatic, hematologic, pulmonary, etc., which might limit the ability to complete this study
• History of malignancy with metastasis to the musculoskeletal system
• Neuromuscular disease impairing balance to the degree of not being able to stand without assistance
• BMD T-score of less than -3.5 at any measured site and a prior hip or vertebral fracture

• Minimum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Wisconsin, Madison

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Neil Binkley, MD

Role: PRINCIPAL_INVESTIGATOR

University of Wisconsin, Madison

Locations

University of Wisconsin Osteoporosis Clinical Center and Research Program

Madison, Wisconsin, United States

Countries

United States

Other Identifiers

H-2010-0011

Identifier Type: -

Identifier Source: org_study_id