Neurally Adjusted Ventilatory Assist (NAVA) in Ventilatory Care of Premature Infants

NCT ID: NCT01156467

Last Updated: 2013-06-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-04-30

Study Completion Date

2013-06-30

Brief Summary

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The purpose of this study is to find out, whether it is possible to improve the ventilatory care of premature infants by using Neurally adjusted ventilatory assist (NAVA).

The study hypothesis is that by using NAVA-technology and/or by monitoring Edi-signal (the electrical signal of diaphragm), it is possible to accomplish ventilatory care to premature infants more individually.

Detailed Description

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Asynchrony means that the timing of support given by the ventilator is different from patients own breathing pattern. Asynchrony during ventilatory care may increase the risk for complications especially in premature infants with immature lungs.

In this study investigators will compare currently used ventilation methods to a new neurally adjusted ventilatory assist (NAVA). The aim is to find out, whether by using this new method it is possible to decrease the complications associated to ventilatory care and to shorten the need for mechanical ventilation.

Conditions

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Ventilation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Control

Infants randomised to this arm will receive a regular nasogastric tube, and the ventilatory care is given as routinely is done.

Group Type ACTIVE_COMPARATOR

Control group, ventilation with i-Servo or Stephanie

Intervention Type DEVICE

Ventilatory support is given as routinely is done in the neonatal intensive care unit, with the ventilators available. Normal nasogastric tube is used.

NAVA

Infants randomised to this arm will receive and Edi-catheter as an oro-/nasogastric tube and the Edi-signal will be monitored and when possible NAVA-ventilation used.

Group Type ACTIVE_COMPARATOR

Neurally adjusted ventilatory assist, i-Servo, Maquet Nordic (Solna, Sweden)

Intervention Type DEVICE

Treatment with Edi-catheter

Interventions

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Neurally adjusted ventilatory assist, i-Servo, Maquet Nordic (Solna, Sweden)

Treatment with Edi-catheter

Intervention Type DEVICE

Control group, ventilation with i-Servo or Stephanie

Ventilatory support is given as routinely is done in the neonatal intensive care unit, with the ventilators available. Normal nasogastric tube is used.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* All children of postconceptional age from 28+0 to 36+6 weeks needing mechanical ventilation for at least 60 minutes

Exclusion Criteria

* severe birth asphyxia, malformations, chromosomal abnormality or other condition, which will decrease the length of life
* condition which prevents the positioning of an oro-/nasogastric tube
Maximum Eligible Age

9 Weeks

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Oulu

OTHER

Sponsor Role lead

Responsible Party

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Merja Ålander

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Timo Saarela, MD, PhD

Role: STUDY_DIRECTOR

Oulu University Hospital

Merja Ålander, MD

Role: PRINCIPAL_INVESTIGATOR

Oulu University Hospital

Locations

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University hospital of Oulu

Oulu, North Ostrobothnia, Finland

Site Status

Countries

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Finland

Other Identifiers

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EETTMK:26/2010

Identifier Type: -

Identifier Source: org_study_id

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