Comparison of NIV-NAVA vs. N-CPAP After Extubation in Preterm Infants Study

NCT ID: NCT02590757

Last Updated: 2021-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

78 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-12-10

Study Completion Date

2021-01-23

Brief Summary

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This study is a randomized controlled study to compare if a a non-invasive neurally adjusted ventilatory assist (NIV-NAVA) is better than nasal continuous positive airway pressure (N-CPAP) after extubation in infants' \< 30 weeks of gestation.

Detailed Description

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Conditions

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Endotracheal Extubation Infant, Premature

Keywords

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non-invasive ventilation non-invasive neurally adjusted ventilatory assist nasal continuous positive airway pressure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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NIV-NAVA

Noninvasive ventilation in this group is practiced with NIV-NAVA

Group Type ACTIVE_COMPARATOR

NIV-NAVA

Intervention Type DEVICE

Non-invasive neurally adjusted ventilatory assist

N-CPAP

Patients in this group will receive nasal continuous positive airway pressure as routinely in neonatal intensive care unit.

Group Type ACTIVE_COMPARATOR

N-CPAP

Intervention Type DEVICE

Nasal-continuous positive airway pressure

Interventions

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NIV-NAVA

Non-invasive neurally adjusted ventilatory assist

Intervention Type DEVICE

N-CPAP

Nasal-continuous positive airway pressure

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* postconceptional age less than 30+0 weeks
* infants who fulfill the the criteria for extubation for 6 hours extubation criteria: Ventilator rate ≤ 25 breaths/min, Peak inspiratory pressure (PIP) ≤ 16cmH2O, Fractional inspired oxygen (FiO2) ≤ 0.3

Exclusion Criteria

* conditions which will decrease life expectancy
* major anomalies which will decrease life expectancy
* any anomalous conditions which involve upper and lower airway
* neuromuscular disease
Minimum Eligible Age

2 Days

Maximum Eligible Age

6 Weeks

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Han-Suk Kim

Professor, Director of Neonatal Intensive Care Unit

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Han-Suk Kim, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Hospital

Locations

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Seoul National University Children's Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

References

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Shin SH, Shin SH, Kim SH, Song IG, Jung YH, Kim EK, Kim HS. Noninvasive Neurally Adjusted Ventilation in Postextubation Stabilization of Preterm Infants: A Randomized Controlled Study. J Pediatr. 2022 Aug;247:53-59.e1. doi: 10.1016/j.jpeds.2022.04.025. Epub 2022 Apr 20.

Reference Type DERIVED
PMID: 35460702 (View on PubMed)

Other Identifiers

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2015-1917

Identifier Type: -

Identifier Source: org_study_id