Neural Mechanisms in Asthma

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

31 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-10-31

Study Completion Date

2014-11-30

Brief Summary

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Asthma is a chronic disease that affects nearly 13% of adults in the U.S., causing substantial impairment that is reflected in the tens of millions of missed days of work, and doctors' and emergency room visits it leads to annually. Those who have asthma are twice as likely to develop depression and anxiety, which are associated with more frequent and severe asthma symptoms, especially in those under chronic stress. The project proposed here seeks to understand the role of the brain in these associations and to evaluate the neural mechanisms through which a safe, low-cost intervention, that influences the function of body via the mind, may diminish the expression of asthma symptoms.

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Detailed Description

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Conditions

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Asthma

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Asthmatic, chronic stress

No interventions assigned to this group

Asthmatic, non-stress

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Asthmatics:

* Physician diagnosed asthma with previous use of asthma medication
* Controls:

* negative skin-prick test to cat dander or house dust mite and have no history of asthma
* Chronic Stress:

* score 3 or above on any subscale of the UCLA (University of California Los Angeles) chronic stress interview

No chronic stress:

score 1.5 or below on all subscales of the UCLA chronic stress interview

Exclusion Criteria

* Individuals with severe asthma, or those whom currently require the use of corticosteroids
* Individuals with significant medical problems
* Individuals who smoke cigarettes
* Individuals a previous adverse reaction to corticosteroids, a recent (\< 1 month) viral illness, a history of severe asthma or anaphylaxis.
* Breastfeeding women or women who are, suspect they might be or are trying to become pregnant

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes