Childhood Origins of Asthma (COAST)

NCT ID: NCT00204841

Last Updated: 2019-07-15

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 287 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 1998-10-31
• Study Completion Date: 2019-06-30

Brief Summary

Although asthma is likely to be a heterogeneous disease or syndrome, three factors and/or events repetitively emerge for their ability to significantly influence asthma inception in the first decade of life: immune response aberrations, which appear to be defined best by the concept of cytokine dysregulation; lower respiratory tract infections (in particular RSV); and some form of gene by environment interaction that needs to occur at a critical time period in the development of the immune system or the lung. It remains to be firmly established, however, how any one or all of these factors, either independently or interactively, influence the development of childhood asthma. Thus, our efforts to determine and define the importance of these three factors to asthma pathogenesis are the focus and goal of this current grant application.

Detailed Description

No more description necessary.

Conditions

Asthma; Allergy

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• children who had one or more parent with a history of allergy or asthma

Exclusion Criteria

• pre term infants
• low birth weight infants
• respiratory distress at birth

• Minimum Eligible Age: 1 Minute
• Maximum Eligible Age: 2 Minutes
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Institutes of Health (NIH)

NIH

Sponsor Role: collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role: collaborator

University of Wisconsin, Madison

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Daniel J Jackson, MD

Role: PRINCIPAL_INVESTIGATOR

University of Wisconsin, Madison

Robert F Lemanske, Jr., MD

Role: PRINCIPAL_INVESTIGATOR

University of Wisconsin, Madison

Locations

University of Wisconsin

Madison, Wisconsin, United States

Countries

United States

Related Links

http://www.medicine.wisc.edu/research/researchmain

study web page

Other Identifiers

P01HL070831

Identifier Type: NIH

Identifier Source: secondary_id

View Link

2013-0144

Identifier Type: OTHER

Identifier Source: secondary_id

H-2007-0044

Identifier Type: OTHER

Identifier Source: secondary_id

1998-129

Identifier Type: -

Identifier Source: org_study_id