Bright Light as a Countermeasure for Circadian Desynchrony
NCT ID: NCT01119365
Last Updated: 2022-04-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
300 participants
INTERVENTIONAL
2011-07-31
2023-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
DOUBLE
Study Groups
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Light
Sequence of bright light flashes of varying durations, interflash intervals, flash lengths, flash brightness, and flash color.
Bright light
Light is administered through a custom designed mask with LED lights.
Interventions
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Bright light
Light is administered through a custom designed mask with LED lights.
Eligibility Criteria
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Inclusion Criteria
* Normal hearing
Exclusion Criteria
* Extreme chronotype
* Regular smoker
* Depression
* Alcohol abuse
* Illegal drug use
18 Years
35 Years
ALL
Yes
Sponsors
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Stanford University
OTHER
Palo Alto Veterans Institute for Research
OTHER
VA Palo Alto Health Care System
FED
Responsible Party
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Jamie M. Zeitzer, Ph.D.
Associate Professor
Principal Investigators
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Jamie M Zeitzer, PhD
Role: PRINCIPAL_INVESTIGATOR
Stanford University/VAPAHCS
Locations
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VA Palo Alto Health Care System
Palo Alto, California, United States
Countries
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Central Contacts
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References
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Zeitzer JM, Dijk DJ, Kronauer R, Brown E, Czeisler C. Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression. J Physiol. 2000 Aug 1;526 Pt 3(Pt 3):695-702. doi: 10.1111/j.1469-7793.2000.00695.x.
Cajochen C, Zeitzer JM, Czeisler CA, Dijk DJ. Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness. Behav Brain Res. 2000 Oct;115(1):75-83. doi: 10.1016/s0166-4328(00)00236-9.
Zeitzer JM, Khalsa SB, Boivin DB, Duffy JF, Shanahan TL, Kronauer RE, Czeisler CA. Temporal dynamics of late-night photic stimulation of the human circadian timing system. Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R839-44. doi: 10.1152/ajpregu.00232.2005. Epub 2005 May 12.
Zeitzer JM, Ruby NF, Fisicaro RA, Heller HC. Response of the human circadian system to millisecond flashes of light. PLoS One. 2011;6(7):e22078. doi: 10.1371/journal.pone.0022078. Epub 2011 Jul 8.
Zeitzer JM, Fisicaro RA, Ruby NF, Heller HC. Millisecond flashes of light phase delay the human circadian clock during sleep. J Biol Rhythms. 2014 Oct;29(5):370-6. doi: 10.1177/0748730414546532. Epub 2014 Sep 16.
Najjar RP, Zeitzer JM. Temporal integration of light flashes by the human circadian system. J Clin Invest. 2016 Mar 1;126(3):938-47. doi: 10.1172/JCI82306. Epub 2016 Feb 8.
Joyce DS, Spitschan M, Zeitzer JM. Duration invariance and intensity dependence of the human circadian system phase shifting response to brief light flashes. Proc Biol Sci. 2022 Mar 9;289(1970):20211943. doi: 10.1098/rspb.2021.1943. Epub 2022 Mar 9.
Other Identifiers
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10165
Identifier Type: -
Identifier Source: org_study_id
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