Research on Outpatient Adolescent Treatment for Comorbid Substance Use and Internalizing Disorders

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

140 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-07-31

Study Completion Date

2014-06-30

Brief Summary

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Adolescent substance abuse results in significant negative outcomes and extraordinary costs for youths, their families, communities, and society. Moreover, rates of psychiatric comorbidity among substance abusing youth range from 25% up to 82%, and youths with a dual diagnosis are more than twice as costly to treat compared to those with no comorbidity. The applicant principal investigator recently completed a pilot project funded by the National Institute on Drug Abuse focused on developing and piloting a psychosocial treatment specifically for youth presenting for outpatient treatment with co-occurring substance use and internalizing (i.e., mood and/or anxiety) problems. Results were promising with the experimental group exhibiting significantly less substance use and more rapid reductions in anxiety and depressive symptoms compared to the control group. The proposed research is a randomized clinical trial (RCT) to compare the experimental treatment (OutPatient Treatment for Adolescents; OPT-A) to an "active placebo" on key clinical indices from pre-treatment through 18 months. The proposed RCT (n = 160) employs the treatment manual, quality assurance protocol, and therapist training protocol developed and successfully tested in the pilot study, to evaluate the efficacy of OPT-A for youth referred to outpatient treatment of co-occurring substance use and internalizing problems. The following outcomes will be evaluated: drug use; mental health; behavioral, school, peer, and family functioning; and consumer satisfaction. The intervention addresses one of the more prevalent and most challenging, costly, and understudied presenting problems among adolescent outpatients. If successful, this research could provide a considerable contribution in the treatment field for youth with co-occurring substance use and internalizing disorders.

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Detailed Description

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Conditions

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Substance-Related Disorders Depressive Disorder Anxiety Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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OPT-A

OPT-A is an outpatient family-based treatment for co-occurring substance use and internalizing disorders

Group Type EXPERIMENTAL

OutPatient Treatment for Adolescents (OPT-A)

Intervention Type BEHAVIORAL

Treatment as Usual

Treatment as usual in a community based mental health center

Group Type ACTIVE_COMPARATOR

Treatment As Usual

Intervention Type BEHAVIORAL

Interventions

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OutPatient Treatment for Adolescents (OPT-A)

Intervention Type BEHAVIORAL

Treatment As Usual

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* 10 to 17 years of age
* Residing with at least one adult caregiver who serves as a parent figure
* In need of treatment for a Substance Abuse or Dependence Disorder
* In need of treatment for an Axis I Mood Disorder and/or Anxiety Disorder