A Pilot Study of Filtrum-STI in Children With Viral Gastroenteritis

NCT ID: NCT01113346

Last Updated: 2010-07-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2/PHASE3

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-06-30

Study Completion Date

2011-02-28

Brief Summary

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This is a phase II double blind multicenter randomized placebo-controled clinical study aimed to find out whether treatment with Filtrum-STI (orally administered 0,4g tablets) is safe and effective in children with viral gastroenteritis. Filtrum-STI (lignin hydrolytic) is a drug with a high absorbing ability, that binds and eliminates toxins, pathogenic microorganisms and viruses. Filtrum-STI is inoffensive for mucous membranes, enhances colonic propulsion and improves its natural microflora. The drug is not toxic and well combines with other medication

Detailed Description

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Conditions

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Viral Gastroenteritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Filtrum-STI

Group Type EXPERIMENTAL

Filtrum-STI (lignin hydrolytic)

Intervention Type DRUG

For children aged less than 1 y.o.: Filtrum-STI, 400mg per day (1/2 tablet 2 times a day) for 7 days.

For children aged 1-4 y.o.: Filtrum-STI, 800mg per day (1 tablet 2 times a day) for 7 days.

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

For children aged less than 1 y.o.: Placebo, 1/2 tablet 2 times a day for 7 days.

For children aged 1-4 y.o.: Placebo, 1 tablet 2 times a day for 7 days.

Interventions

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Filtrum-STI (lignin hydrolytic)

For children aged less than 1 y.o.: Filtrum-STI, 400mg per day (1/2 tablet 2 times a day) for 7 days.

For children aged 1-4 y.o.: Filtrum-STI, 800mg per day (1 tablet 2 times a day) for 7 days.

Intervention Type DRUG

Placebo

For children aged less than 1 y.o.: Placebo, 1/2 tablet 2 times a day for 7 days.

For children aged 1-4 y.o.: Placebo, 1 tablet 2 times a day for 7 days.

Intervention Type DRUG

Other Intervention Names

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lignin hydrolytic, sorbent, enterosorbent

Eligibility Criteria

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Inclusion Criteria

* children aged 0-4 y.o. diagnosed with moderate viral gastroenteritis;
* 72 h or less from the onset of gastrointestinal symptoms.

Exclusion Criteria

* severe diseases;
* individual intolerance of Filtrum-STI
* treatment with antiviral, immunomodulatory drugs during the study and 2 weeks before inclusion
* treatment with pre- pro- and antibiotics 2 weeks before inclusion
* participation in other clinical study 1 month before inclusion and during participation in the study.
Minimum Eligible Age

1 Month

Maximum Eligible Age

4 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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St. Vladimir Moscow Children's Clinical Hospital

UNKNOWN

Sponsor Role collaborator

Arhangelsk Regional Children's Clinical Hospital named after Vizshletsov P.G.

UNKNOWN

Sponsor Role collaborator

Avva Rus, JSC

INDUSTRY

Sponsor Role lead

Responsible Party

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St. Vladimir Moscow Children's Clinical Hospital

Principal Investigators

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Elena Meskina, MD, DrSc

Role: PRINCIPAL_INVESTIGATOR

St. Vladimir Children's Moscow Clinical Hospital

Lyudmila Kobeleva, MD, PhD

Role: STUDY_DIRECTOR

Avva Rus, JSC

Nickolay A. Kryuchkov, MD, PhD, MPH

Role: STUDY_DIRECTOR

Avva Rus, JSC

Locations

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Arhangelsk Regional Children's Clinical Hospital named after P.G. Vizshletsov

Arhangelsk, Arhangelskaya Oblast, Russia

Site Status RECRUITING

St. Vladimir Children's Moscow Clinical Hospital

Moscow, Moscow, Russia

Site Status RECRUITING

Countries

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Russia

Central Contacts

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Lyudmila Kobeleva, MD, PhD

Role: CONTACT

+7-495-9567559

Nickolay Kryuchkov, MD, PhD, MPH

Role: CONTACT

+7-495-9567559

Facility Contacts

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Larisa Titova, MD, PhD

Role: primary

+7-8182-280433

Olga Samodova, MD, DrSc

Role: backup

+7-8182-22-95-42

Elena Meskina, MD, DrSc

Role: primary

+7-916-1216172

Lyudmila Feklisova, MD, DrSc

Role: backup

+7-495-2682226

Other Identifiers

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03/09-AVVA RUS

Identifier Type: -

Identifier Source: org_study_id

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