Efficacy of Racecadotril in Acute Watery Diarrhea in Children

NCT ID: NCT01577043

Last Updated: 2012-04-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

52 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-09-30

Study Completion Date

2012-04-30

Brief Summary

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The purpose of this study is to determine the effect of racecadotril in acute watery diarrhea in children. The investigators will evaluate the effect of product versus placebo.

Detailed Description

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Background: Treatment of acute diarrhea is based on the following various oral rehydration management guidelines. Lately other drugs currently under investigation as antisecretory drugs to shorten the diarrheal episode and can be used safely in children.

Objectives: To evaluate the effect of racecadotril in the treatment of children under 5 years of age with acute diarrhea.

Methods: A randomized clinical trial, controlled, double-blind. The investigators will have two groups of patients: One group will receive racecadotril plus oral rehydration and the other one will receive placebo plus oral rehydration; the parameters of evaluation are going to be the duration of diarrheal episode, number of stools by day, weight of stool, nutritional state.

Conditions

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Acute Diarrhea Acute Gastroenteritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Racecadotril

intestinal antisecretory

Group Type ACTIVE_COMPARATOR

Racecadotril

Intervention Type DRUG

Racecadotril, 30 mg per sachet, dosage 1.5 mg./kg./day

cornstach solution

Cornstarch powder diluted in distilled water

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

cornstarch powder diluted in distilled water, dosage 2.5 ml per dose

Interventions

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Racecadotril

Racecadotril, 30 mg per sachet, dosage 1.5 mg./kg./day

Intervention Type DRUG

Placebo

cornstarch powder diluted in distilled water, dosage 2.5 ml per dose

Intervention Type OTHER

Other Intervention Names

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Hidrasec

Eligibility Criteria

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Inclusion Criteria

* Acute watery diarrhea

Exclusion Criteria

* Severe malnourishment
* Severe dehydration
* Systemic infections
* Coinfections
Minimum Eligible Age

6 Months

Maximum Eligible Age

59 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centro Pediatrico Albina de Patino

OTHER

Sponsor Role lead

Responsible Party

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Giuseppe Grandy

Medical Chief of Nutrition Center

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Giuseppe Grandy, MD MSc

Role: STUDY_DIRECTOR

Centro Pediatrico Albina de Ptino

Richard Soria, MD

Role: PRINCIPAL_INVESTIGATOR

Centro Pediatrico Albina de Patino

Jackeline Torrez, MD

Role: STUDY_CHAIR

Centro Pediatrico Albina de Patino

Locations

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Centro Pediatrico Albina de Patino

Cochabamba, Departamento de Cochabamba, Bolivia

Site Status

Countries

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Bolivia

Other Identifiers

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protracec2011

Identifier Type: -

Identifier Source: org_study_id

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