Characterization of Proliferating Compartment in B-Cell Patients and in Healthy Aging Subjects

NCT ID: NCT01110863

Last Updated: 2021-03-03

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 90 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2005-12-31
• Study Completion Date: 2016-02-12

Brief Summary

By ingesting a non-radioactive and non-toxic compound "heavy water" for 6 weeks, the DNA of newly developed cells in the body of subjects with B-cell chronic lymphocytic leukemia can be labeled and followed by performing routine blood draws at specified time intervals. By using mass spectrometric analysis we can measure how quickly new B-CLL cells are generated in the bone marrow and how quickly they leave the blood, a measure of cell turnover. This will help us to better understand the unique characteristics of this disease process.

Detailed Description

By ingesting a non-radioactive and non-toxic compound "heavy water" for 6 weeks, the DNA of newly developed cells in the body of subjects with B-cell chronic lymphocytic leukemia (B-CLL) can be labeled and followed by performing routine blood draws at specified time intervals. By using mass spectrometric analysis we can measure how quickly new B-CLL cells are generated in the bone marrow and how quickly they leave the blood, a measure of cell turnover. This will help us to better understand the unique characteristics of this disease process.

Conditions

Chronic Lymphocytic Leukemia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• 18 years of age,
• Patients must be willing to contribute the required amount of blood without compromising their well being,
• Participants must be willing to be contacted in the future.

Exclusion Criteria

• Pregnancy,
• Patients who are known to be anemic, with a hemoglobin < 8,
• Patients who are known to be infected with HIV.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Northwell Health

OTHER

Sponsor Role: lead

Responsible Party

Nicholas Chiorazzi

Investigator, The Feinstein Institute for Medical Research

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Nicholas Chiorazzi, MD

Role: PRINCIPAL_INVESTIGATOR

Feinstein Institute for Medical Research

Locations

Feinstein Institute for Medical Research

Manhasset, New York, United States

Countries

United States

Other Identifiers

GAC # 0117

Identifier Type: OTHER

Identifier Source: secondary_id

05-05-096

Identifier Type: -

Identifier Source: org_study_id