B Cell Repertoires in Chronic Lymphocytic Leukemia and Aging

NCT ID: NCT01028430

Last Updated: 2024-03-27

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 1000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 1998-07-31
• Study Completion Date: 2023-09-30

Brief Summary

B-CLL is the most prevalent leukemia in the Western hemisphere, accounting for ~25% of all leukemia's (1). This disease occurs virtually exclusively in the aging population, with the median age of diagnosis ranging between the mid 60s and the early 70s. Indeed, its occurrence before the age of 50 is quite unusual. This increase in occurrence with age is not unique to B-CLL; rather, it is characteristic several B cell lymphoproliferative disorders (e.g., non-Hodgkin's lymphoma, multiple myeloma). Gender and race also influence the development of B-CLL. Thus, the ratio of men: women is ~2:1 and the prevalence is increased in Caucasians. The rate of occurrence of B-CLL among Asians is significantly lower than for Caucasians and this does not increase with immigration to the West. DNA sequence analyses performed in our laboratory and in those of others indicate that B-CLL cells from unrelated patients share Ig V gene characteristics. These include the use of selected genes, the association of these genes with certain D and JH gene segments that code for unique CDR3 motifs, and the occasional occurrence of highly similar VHDJH + VLJL pairs. In ~50% cases, these rearranged genes are mutated, whereas in the others mutations are infrequent; this difference is related to the VH gene family used by the B-CLL cell.

Conditions

Chronic Lymphocytic Leukemia

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• 18 years of age Patients must be willing to be contacted in the future

Exclusion Criteria

• Patients who are known to be anemic, with a hemoglobin <8 PAtients who are known to be infected with HIV

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Northwell Health

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Nicholas Chiorazzi, MD

Role: PRINCIPAL_INVESTIGATOR

Northwell Health

Locations

Feinstein Institute for Medical Research

Manhasset, New York, United States

Countries

United States

Other Identifiers

04-046

Identifier Type: -

Identifier Source: org_study_id