Effectiveness, Safety and Feasibility of Auxiliary Nurse Midwives' (ANM) Use of Oxytocin in Uniject™ to Prevent Postpartum Hemorrhage in India

NCT ID: NCT01108302

Last Updated: 2012-01-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2011-09-30

Study Completion Date

2013-06-30

Brief Summary

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This cluster randomized community-based trial is designed to test the hypothesis that the intramuscular administration of 10 IU of oxytocin in Uniject™ during the third stage of labor by an Auxiliary Nurse Midwife (ANM) at births occurring in homes, Sub-Centers and Primary Health Centers in Bagalkot, India will reduce the risk of postpartum hemorrhage by 44% (from 9% to 5%) relative to home births attended by the same type of provider who does not provide the intervention drug. The study will also document correct use of oxytocin in Uniject, adverse maternal and fetal events associated with inappropriate use and a number of indicators reflecting the programmatic feasibility of implementing this intervention.

Detailed Description

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Conditions

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Postpartum Hemorrhage

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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PPH Treatment only

Auxilliary nurse midwives will be able to treat for PPH only, not provide Oxytocin in Uniject

Group Type NO_INTERVENTION

No interventions assigned to this group

Oxytocin in Uniject

Auxilliary Nurse Midwives will provide 10IU Oxytocin in Uniject device IM immediately after delivery

Group Type EXPERIMENTAL

Oxytocin in Uniject

Intervention Type OTHER

10 IU Oxytocin delivered intramuscularly immediately after delivery of the baby

Interventions

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Oxytocin in Uniject

10 IU Oxytocin delivered intramuscularly immediately after delivery of the baby

Intervention Type OTHER

Other Intervention Names

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Pitocin, Syntocinon

Eligibility Criteria

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Inclusion Criteria

* gestational age \>=28 wks at enrollment
* anticipate spontaneous vaginal delivery
* hemoglobin \>=8 gm/dl
* delivery at home, sub-center, or primary health center
* delivery attended by Auxilliary Nurse Midwife

Exclusion Criteria

* previous caesarean-section
* scheduled for caesarean-section
* antepartum bleeding during current pregnancy
* blood pressure \>140mm of Hg systolic and \>90mm of Hg diastolic
* in active labor at time of recruitment
* high risk medical conditions (diabetes, cardiac ailments, seizures, placenta previa, anticipated breech delivery
Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Jawaharlal Nehru Medical College Women's and Children's Health Research Unit

UNKNOWN

Sponsor Role collaborator

PATH

OTHER

Sponsor Role collaborator

Bill and Melinda Gates Foundation

OTHER

Sponsor Role collaborator

Johns Hopkins Bloomberg School of Public Health

OTHER

Sponsor Role lead

Responsible Party

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Johns Hopkins Bloomberg School of Public Health

Principal Investigators

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Cynthia Stanton, PhD

Role: PRINCIPAL_INVESTIGATOR

Johns Hopkins Bloomberg School of Public Health

Shivaprasad Goudar, MD

Role: PRINCIPAL_INVESTIGATOR

JN Medical College, Belgaum, India

Locations

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Jawaharlal Nehru Medical College Women's and Children's Health Research Unit

Belagavi, Karnataka, India

Site Status

Countries

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India

Other Identifiers

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GAT.1429-07882-2

Identifier Type: -

Identifier Source: org_study_id

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