A Trial Examining the Treatment of Common Warts With Combination Liquid Nitrogen (LN2) and Cantharidin
NCT ID: NCT01084824
Last Updated: 2010-03-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
70 participants
INTERVENTIONAL
2007-06-30
2008-09-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Liquid nitrogen and canthardin
Liquid nitrogen applied to wart(s), then cantharidin 1% topical applied afterwards.
Liquid nitrogen and cantharidin
Liquid nitrogen applied to wart(s), then cantharidin 1% topical applied afterward.
Liquid nitrogen and placebo
Liquid nitrogen applied to wart(s) then placebo vehicle afterwards.
Liquid nitrogen and topical placebo
Liquid nitrogen applied to wart(s), then placebo vehicle applied thereafter.
Interventions
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Liquid nitrogen and cantharidin
Liquid nitrogen applied to wart(s), then cantharidin 1% topical applied afterward.
Liquid nitrogen and topical placebo
Liquid nitrogen applied to wart(s), then placebo vehicle applied thereafter.
Eligibility Criteria
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Inclusion Criteria
2. otherwise healthy
3. between 18-65 and able to give informed consent
4. capable of tolerating treatment
Exclusion Criteria
2. Poor tolerance or sensitivity to treatments in study
3. \<18 years old; \>65 years old
4. verruca plana or condyloma acuminata
5. immunosuppression or immune dysfunction
6. significant peripheral vascular disease
7. significant sensitivity to cold
8. epidermodysplasia verruciformis
9. mosaiform warts or periungual warts
18 Years
65 Years
ALL
Yes
Sponsors
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North Idaho Dermatology
OTHER
Responsible Party
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North Idaho Dermatology, TUI University
Principal Investigators
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Richard A Flygare, PhD
Role: PRINCIPAL_INVESTIGATOR
TUI University; North Idaho Dermatology
Locations
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North Idaho Dermatology
Coeur d'Alene, Idaho, United States
Countries
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References
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Berth-Jones J, Bourke J, Eglitis H, Harper C, Kirk P, Pavord S, Rajapakse R, Weston P, Wiggins T, Hutchinson PE. Value of a second freeze-thaw cycle in cryotherapy of common warts. Br J Dermatol. 1994 Dec;131(6):883-6. doi: 10.1111/j.1365-2133.1994.tb08594.x.
Guidelines of care for cryosurgery. American Academy of Dermatology Committee on Guidelines of Care. J Am Acad Dermatol. 1994 Oct;31(4):648-53. No abstract available.
Moed L, Shwayder TA, Chang MW. Cantharidin revisited: a blistering defense of an ancient medicine. Arch Dermatol. 2001 Oct;137(10):1357-60. doi: 10.1001/archderm.137.10.1357.
Other Identifiers
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NID-001
Identifier Type: -
Identifier Source: org_study_id
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